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MCCC2 Antibody

  • 中文名稱:
    MCCC2兔多克隆抗體
  • 貨號:
    CSB-PA867199ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: MCCC2 antibody at 6.85µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Hela whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: K562 whole cell lysate
      Lane 5: HepG2 whole cell lysate
      Lane 6: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 62, 58 kDa
      Observed band size: 62 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA867199ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA867199ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MCCC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MCCC2
  • 別名:
    MCCC2 antibody; MCCBMethylcrotonoyl-CoA carboxylase beta chain antibody; mitochondrial antibody; MCCase subunit beta antibody; EC 6.4.1.4 antibody; 3-methylcrotonyl-CoA carboxylase 2 antibody; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit antibody; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial protein (284-563AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
  • 基因功能參考文獻:
    1. Novel mutation in MCCC2 gene was identified in Chinese population. PMID: 25382614
    2. Mutation in 3-methylcrotonyl CoA carboxylase 2 gene is associated with 3-methylcrotonyl-CoA carboxylase deficiency. PMID: 22264772
    3. The amino-termini containing 20 amino acids (MCCbeta) were both necessary and sufficient for targeting. Structural requirements for mitochondrial import were defined by site-directed mutagenesis. PMID: 16023992
    4. The Kd value of soraphen A for the BC domains of human ACC1 and ACC2 is 1 nM. This high binding affinity is mainly due to the extensive interactions between soraphen A and the human biotin carboxylase domain PMID: 17876819
  • 相關疾病:
    3-methylcrotonoyl-CoA carboxylase 2 deficiency (MCC2D)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    AccD/PCCB family
  • 數據庫鏈接:

    HGNC: 6937

    OMIM: 210210

    KEGG: hsa:64087

    STRING: 9606.ENSP00000343657

    UniGene: Hs.604789



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