在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MBD5 Antibody

  • 中文名稱:
    MBD5兔多克隆抗體
  • 貨號:
    CSB-PA868388LA01HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MBD5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MBD5
  • 別名:
    9430004D19Rik antibody; AA536666 antibody; AI426407 antibody; C030040A15Rik antibody; FLJ11113 antibody; FLJ30517 antibody; KIAA1461 antibody; MBD5 antibody; MBD5_HUMAN antibody; methyl CpG binding domain protein 5 antibody; Methyl CpG binding protein MBD5 antibody; Methyl-CpG-binding domain protein 5 antibody; Methyl-CpG-binding protein MBD5 antibody; RP23 167N13.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Methyl-CpG-binding domain protein 5 protein (623-840AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,MBD5 Antibody (CSB-PA868388LA01HU),的標記方式是Non-conjugated。對于MBD5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA868388LB01HU MBD5 Antibody, HRP conjugated ELISA
    FITC CSB-PA868388LC01HU MBD5 Antibody, FITC conjugated
    Biotin CSB-PA868388LD01HU MBD5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
  • 基因功能參考文獻:
    1. Based on segregation analysis of a patient (case 296491) with an intragenic deletion of the MBD5 gene, we classified deletions of exons 3 to 4 of the 5' untranslated region (UTR) of this gene as probably benign. The deletion of exon 3 was shared with the father and paternal uncle, both unaffected PMID: 28295210
    2. A novel frameshift mutation c.254_255delGA (p.Arg85Asnfs*6) in the MBD5 gene was identified in a family with intellectual disability and epilepsy. PMID: 28807762
    3. Circadian rhythm gene expression altered by haploinsufficiency of MBD5. PMID: 25271084
    4. Results show that when MBD5 and RAI1 are haploinsufficient, they perturb several common pathways that are linked to neuronal and behavioral development. PMID: 25853262
    5. Reduced MBD5 dosage leads to mRNA and microRNA expression patterns and DNA methylation patterns more characteristic of differentiating than proliferating neural stem cells. This balance change may underlie neurodevelopmental disorders. PMID: 25966365
    6. We studied and showed that both MBD5 and MBD6 interact with the mammalian PR-DUB Polycomb protein complex in a mutually exclusive manner, and that the MBD of MBD5 and MBD6 is both necessary and sufficient to mediate this interaction. PMID: 24634419
    7. The features associated with a deletion, mutation or duplication of MBD5 and the gene expression changes observed support MBD5 as a dosage-sensitive gene critical for normal development. PMID: 23632792
    8. study demonstrates that haploinsufficiency of MBD5 causes diverse phenotypes, yields insight into the spectrum of resulting neurodevelopmental and behavioral psychopathology and provides clinical context for interpretation of MBD5 structural variations. PMID: 23587880
    9. A genomic copy number variant analysis implicates the MBD5 and HNRNPU genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion. PMID: 24885232
    10. Identified de novo intragenic deletions of MBD5 in three patients. PMID: 23422940
    11. MBD5 was tied to neurodevelopmental disorders following the identification of microdeletions on chromosome 2q22-2q23. PMID: 23055267
    12. MBD5 is a single causal locus as shown by 2q23.1 microdeletion syndrome with roles in intellectual disability, epilepsy, and autism spectrum disorder PMID: 21981781
    13. 2q23 de novo microdeletion involving the MBD5 gene in a patient with developmental delay, postnatal microcephaly and distinct facial features. PMID: 21271666
    14. MBD5 and MBD6 are unlikely to be methyl-binding proteins, yet they may contribute to the formation or function of heterochromatin. PMID: 20700456
    15. Haploinsufficiency of MBD5 is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures.( PMID: 19904302

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, autosomal dominant 1 (MRD1)
  • 亞細胞定位:
    [Isoform 1]: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.; [Isoform 2]: Nucleus. Note=Not associated with pericentric heterochromatin.
  • 組織特異性:
    Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 20444

    OMIM: 156200

    KEGG: hsa:55777

    STRING: 9606.ENSP00000386049

    UniGene: Hs.458312



主站蜘蛛池模板: 国产乡下三级全黄三级| 亚洲日本中文字幕乱码在线 | 国产精品无码mv在线观看| 日本中文一二区有码在线| 国产成人夜色高潮福利影视| 免费观看成人毛片a片| 日日干夜夜干| 伊人久久大香线蕉av最新| 亚洲国产精品自在拍在线播放蜜臀 | 忘忧草日本在线www| 日韩av高潮喷水在线观看| 国产精品美女久久久久av超清| 国外av无码精品国产精品 | 97超碰国产精品无码分类| 97久久精品人人槡人妻人| 亚洲精品一区二区三区四区五区| 中文字幕人成乱码熟女香港 | 无人去码一码二码三码区| 亚洲欧美在线观看| 亚洲的天堂av无码| 国产粉嫩小泬在线观看泬| 亚洲综合色88综合天堂| 唐人社导航福利精品| 香蕉在线精品视频在线| 色综合a怡红院怡红院| 色在线 | 国产| 免费看成人欧美片爱潮app| 午夜理论片在线观看免费| 亚洲综合激情另类专区| 高潮毛片又色又爽免费| 18禁勿入午夜网站入口| 中国少妇偷人hd| 女性高爱潮视频| 欧美大屁股流白浆xxxx| 免费人成黄页在线观看国产| 国产日产久久高清欧美一区| 亚洲欧美一区二区三区在线| 亚洲aⅴ在线无码播放毛片一线天| 97精品超碰一区二区三区| 欧美一区二区三区久久综合| 99久热re在线精品视频|