在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MBD5 Antibody, HRP conjugated

  • 中文名稱:
    MBD5兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA868388LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MBD5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MBD5
  • 別名:
    9430004D19Rik antibody; AA536666 antibody; AI426407 antibody; C030040A15Rik antibody; FLJ11113 antibody; FLJ30517 antibody; KIAA1461 antibody; MBD5 antibody; MBD5_HUMAN antibody; methyl CpG binding domain protein 5 antibody; Methyl CpG binding protein MBD5 antibody; Methyl-CpG-binding domain protein 5 antibody; Methyl-CpG-binding protein MBD5 antibody; RP23 167N13.1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Methyl-CpG-binding domain protein 5 protein (623-840AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
  • 基因功能參考文獻:
    1. Based on segregation analysis of a patient (case 296491) with an intragenic deletion of the MBD5 gene, we classified deletions of exons 3 to 4 of the 5' untranslated region (UTR) of this gene as probably benign. The deletion of exon 3 was shared with the father and paternal uncle, both unaffected PMID: 28295210
    2. A novel frameshift mutation c.254_255delGA (p.Arg85Asnfs*6) in the MBD5 gene was identified in a family with intellectual disability and epilepsy. PMID: 28807762
    3. Circadian rhythm gene expression altered by haploinsufficiency of MBD5. PMID: 25271084
    4. Results show that when MBD5 and RAI1 are haploinsufficient, they perturb several common pathways that are linked to neuronal and behavioral development. PMID: 25853262
    5. Reduced MBD5 dosage leads to mRNA and microRNA expression patterns and DNA methylation patterns more characteristic of differentiating than proliferating neural stem cells. This balance change may underlie neurodevelopmental disorders. PMID: 25966365
    6. We studied and showed that both MBD5 and MBD6 interact with the mammalian PR-DUB Polycomb protein complex in a mutually exclusive manner, and that the MBD of MBD5 and MBD6 is both necessary and sufficient to mediate this interaction. PMID: 24634419
    7. The features associated with a deletion, mutation or duplication of MBD5 and the gene expression changes observed support MBD5 as a dosage-sensitive gene critical for normal development. PMID: 23632792
    8. study demonstrates that haploinsufficiency of MBD5 causes diverse phenotypes, yields insight into the spectrum of resulting neurodevelopmental and behavioral psychopathology and provides clinical context for interpretation of MBD5 structural variations. PMID: 23587880
    9. A genomic copy number variant analysis implicates the MBD5 and HNRNPU genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion. PMID: 24885232
    10. Identified de novo intragenic deletions of MBD5 in three patients. PMID: 23422940
    11. MBD5 was tied to neurodevelopmental disorders following the identification of microdeletions on chromosome 2q22-2q23. PMID: 23055267
    12. MBD5 is a single causal locus as shown by 2q23.1 microdeletion syndrome with roles in intellectual disability, epilepsy, and autism spectrum disorder PMID: 21981781
    13. 2q23 de novo microdeletion involving the MBD5 gene in a patient with developmental delay, postnatal microcephaly and distinct facial features. PMID: 21271666
    14. MBD5 and MBD6 are unlikely to be methyl-binding proteins, yet they may contribute to the formation or function of heterochromatin. PMID: 20700456
    15. Haploinsufficiency of MBD5 is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures.( PMID: 19904302

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mental retardation, autosomal dominant 1 (MRD1)
  • 亞細胞定位:
    [Isoform 1]: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin.; [Isoform 2]: Nucleus. Note=Not associated with pericentric heterochromatin.
  • 組織特異性:
    Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20444

    OMIM: 156200

    KEGG: hsa:55777

    STRING: 9606.ENSP00000386049

    UniGene: Hs.458312



主站蜘蛛池模板: 成人看片黄a免费看在线| 伊人久久大香线蕉av色婷婷色| 欧美人与动人物牲交免费观看久久 | 十八岁污网站在线观看| 女同免费毛片在线播放| 久久av高潮av无码av| 亚洲国产av美女网站| 日本肉体xxxx裸体137大胆| 7m精品福利视频导航| 五月综合色婷婷在线观看| 国产精品线路一线路二| 亚洲精品中文字幕乱码三区| 国产亚洲精品久久久久久久软件| 久久綾合久久鬼色88| 人妻熟女一区二区aⅴ清水理纱 | 999国产精品999久久久久久| 国产午夜精品一区二区三区老| 亚洲国产制服丝袜高清在线| 少妇人妻真实偷人精品视频| 国产精品久久久久久亚洲影视内衣| 精品国产小视频在线观看| 伊人久久大香线蕉综合狠狠| 后入到高潮免费观看| 美女啪啪网站又黄又免费| 欧美精品九九久久久久久久久| 成人国产一区二区精品小说| 无码精品人妻一区二区三区影院| 日日噜噜夜夜狠狠久久丁香五月| 18成禁人视频免费| 亚洲人成日韩中文字幕无卡| 亚洲 欧美 中文 在线 视频| 国产av精国产传媒| 日日天日日夜日日摸| 曰批视频免费30分钟成人| 一出一进一爽一粗一大视频| 国产亚洲中文日韩欧美综合网| 人澡人人澡人人澡欧美| 亚洲色欲色欲www| 少妇挑战黑人高潮惨叫| 亚洲欧美在线观看品| 99久久人妻无码精品系列蜜桃|