在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAPRE3 Antibody

  • 中文名稱:
    MAPRE3兔多克隆抗體
  • 貨號:
    CSB-PA571087
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA571087(ECE1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA571087(ECE1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse lung tissue, Mouse liver tissue, Primary antibody: CSB-PA571087(ECE1 Antibody) at dilution 1/1050, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MAPRE3
  • 別名:
    APC binding protein antibody; EB 3 antibody; EB1 protein family member 3 antibody; EB3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; EBF3 S antibody; End binding protein 3 antibody; End-binding protein 3 antibody; MAPRE 3 antibody; MAPRE3 antibody; MARE3_HUMAN antibody; Member 3 antibody; Microtubule Associated Protein antibody; Microtubule associated protein RP/EB family member 3 antibody; Microtubule-associated protein RP/EB family member 3 antibody; OTTHUMP00000200910 antibody; RP 3 antibody; RP/EB Family antibody; RP3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human ECE1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. May play a role in cell migration.
  • 基因功能參考文獻:
    1. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified. PMID: 28865014
    2. Findings show that co-ordination of dynamic microtubules and actin filaments by the drebrin/EB3 pathway drives prostate cancer cell invasion and is therefore implicated in disease progression. PMID: 28319065
    3. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs. PMID: 23456299
    4. Daughter cell adhesion and cytokinesis completion are spatially regulated by distinct states of EB3 phosphorylation on serine 176 by Aurora B. PMID: 23712260
    5. decreasing the drebrin E levels disrupted the normal subapical F-actin-myosin-IIB-betaII-spectrin network and the apical accumulation of EB3, a microtubule-plus-end-binding protein PMID: 22275434
    6. VE-cadherin outside-in signaling regulates cytosolic calcium homeostasis and EB3 phosphorylation. PMID: 23159740
    7. study found a polycytosine repeat (C8) in exon 5 of MAPRE3 that could be a potential mutation target in cancers with microsatellite instability (MSI); found that the C8 is frequently mutated in gastric and colorectal carcinomas with MSI PMID: 20632835
    8. The RP3 protein is involved in SATB1-mediated gene repression of Bcl2 and dynein subunit rp3 has functions independent of the dynein motor. PMID: 16079286
    9. Data show that two mitotic kinases, Aurora-A and Aurora-B, phosphorylate endogenous EB3 at Ser-176, and the phosphorylation triggers disruption of the EB3-SIAH-1 complex, resulting in EB3 stabilization during mitosis. PMID: 19696028

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    MAPRE family
  • 組織特異性:
    Predominantly expressed in brain and muscle.
  • 數據庫鏈接:

    HGNC: 6892

    OMIM: 605788

    KEGG: hsa:22924

    STRING: 9606.ENSP00000233121

    UniGene: Hs.515860



主站蜘蛛池模板: 亚洲精品久久国产精品 | 美女张开腿黄网站免费下载| 蜜桃av无码免费看永久| 好爽太紧了舒服视频| 初尝黑人嗷嗷叫中文字幕| 欧洲吸奶大片在线看| 亚洲精品乱码久久久久久蜜桃不卡| 欧美人妻体内射射| 精品无码专区亚洲| 成人性生交大片免费看视频app | 日本一区二区三区免费更新不卡| 亚洲人成网站18禁止大| 久久精品无码av| 亚洲日本va中文字幕| 亚洲精品国产精华液有哪些| 性色av一二三天美传媒| 日韩一区二区三区高清电影| 日本免费一区二区三区最新| 大香线蕉伊人超碰| 亚洲综合久久无码色噜噜| 99久久人妻无码精品系列蜜桃| 色欲久久久天天天综合网| 人妻护士在线波多野结衣| 狠狠色丁香久久综合| 成人永久免费网站在线观看| 成在人线av无码免观看麻豆| 日韩视频无码免费一区=区三区 | 日本一区二区三区免费视频| 亚洲精品成人福利网站| 成人午夜福利视频后入| 精品一区二区三区免费播放| 久久亚洲精品情侣| а√最新版在线天堂| 国产精品国产高清国产av| √8天堂资源地址中文在线| 中文字幕久久精品一区二区三区| 欧美日韩一区二区三区在线观看视频| 欧妇女乱妇女乱视频| 无码专区―va亚洲v专区在线| 亚洲日韩欧美在线成人| 精品少妇人妻av免费久久久|