在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAP4K2 Antibody

  • 中文名稱:
    MAP4K2兔多克隆抗體
  • 貨號:
    CSB-PA013437GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    B lymphocyte serine/threonine protein kinase antibody; B lymphocyte serine/threonine-protein kinase antibody; BL44 antibody; GC kinase antibody; GCK antibody; Germinal center kinase antibody; germinal centre kinase (GC kinase) antibody; M4K2_HUMAN antibody; Map4k2 antibody; MAPK/ERK kinase kinase kinase 2 antibody; MEK kinase kinase 2 antibody; MEKKK 2 antibody; Mitogen activated protein kinase kinase kinase kinase 2 antibody; Mitogen-activated protein kinase kinase kinase kinase 2 antibody; Rab8 interacting protein antibody; Rab8 interacting protein, formerly antibody; Rab8-interacting protein antibody; RAB8IP antibody; RAB8IP, formerly antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human MAP4K2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
  • 基因功能參考文獻:
    1. These studies demonstrate, for the first time, that GCK is a molecular therapeutic target in DLBCL tumors and that inhibiting GCK may significantly extend DLBCL patient survival. PMID: 27151888
    2. Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). PMID: 25075558
    3. Data suggest that the Rabin8-Rab8-Sec15 interaction may couple the activation of Rab8 to the recruitment of the Rab8 effector and is involved in the regulation of vesicular trafficking for primary cilium formation. PMID: 22433857
    4. CCM3 is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. PMID: 20332113
  • 亞細胞定位:
    Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性:
    Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
  • 數據庫鏈接:

    HGNC: 6864

    OMIM: 603166

    KEGG: hsa:5871

    STRING: 9606.ENSP00000294066

    UniGene: Hs.534341



主站蜘蛛池模板: 伊人久久大香线蕉在观看| 亚洲日韩乱码一区二区三区四区 | 99热久久这里只有精品| 无人区乱码区1卡2卡三卡网站| 三级特黄60分钟在线播放| 乱码av麻豆丝袜熟女系列| 潮喷大喷水系列无码视频| 国产成熟妇女性视频电影| 日本大香伊一区二区三区| 精品乱码一区内射人妻无码| 亚洲这里只有久热精品伊人| 亚洲精品久久av无码一区二区| 热久久视久久精品18| 国产精品自在线拍国产手机版| 久久国产主播福利在线| 免费无码又爽又刺激成人| 精品国产一区二区三区四区| 麻豆精产国品| 国产超薄肉色丝袜视频| 国内精品2020情侣视频| 久久久亚洲一区二区三区| 99精品国产一区二区三区| 国产高清-国产av| 国产高清国产精品国产专区| 欧美成年视频在线观看| 极品粉嫩国产18尤物在线观看| 久久www成人片免费看| 92国产精品午夜福利无毒不卡| 激情影院内射美女| 亚洲 日韩 欧美 成人 在线观看| 亚洲国产午夜精品理论片妓女| 国产精品无码久久四虎| 欧美成人一区二免费视频软件| 成人3d动漫一区二区三区| 欧美丰满大乳高跟鞋| 性动态图av无码专区| 香蕉av福利精品导航| 亚洲国产成人超a在线播放| 久久中文骚妇内射| 天天爽天天爽夜夜爽毛片| 丁香婷婷无码不卡在线|