在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), partial

  • 中文名稱:
    人MAP4K2重組蛋白
  • 貨號:
    CSB-YP013437HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MAP4K2重組蛋白
  • 貨號:
    CSB-EP013437HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MAP4K2重組蛋白
  • 貨號:
    CSB-EP013437HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MAP4K2重組蛋白
  • 貨號:
    CSB-BP013437HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MAP4K2重組蛋白
  • 貨號:
    CSB-MP013437HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    B lymphocyte serine/threonine protein kinase ; B lymphocyte serine/threonine-protein kinase; BL44; GC kinase; GCK; Germinal center kinase; germinal centre kinase (GC kinase); M4K2_HUMAN; Map4k2; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Mitogen activated protein kinase kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase kinase 2; Rab8 interacting protein; Rab8 interacting protein, formerly; Rab8-interacting protein; RAB8IP; RAB8IP, formerly
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
  • 基因功能參考文獻:
    1. These studies demonstrate, for the first time, that GCK is a molecular therapeutic target in DLBCL tumors and that inhibiting GCK may significantly extend DLBCL patient survival. PMID: 27151888
    2. Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). PMID: 25075558
    3. Data suggest that the Rabin8-Rab8-Sec15 interaction may couple the activation of Rab8 to the recruitment of the Rab8 effector and is involved in the regulation of vesicular trafficking for primary cilium formation. PMID: 22433857
    4. CCM3 is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. PMID: 20332113
  • 亞細胞定位:
    Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性:
    Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
  • 數據庫鏈接:

    HGNC: 6864

    OMIM: 603166

    KEGG: hsa:5871

    STRING: 9606.ENSP00000294066

    UniGene: Hs.534341



主站蜘蛛池模板: 少妇荡乳情欲办公室456视频| 欧美亚洲精品一区二区| 日本高清成本人视频一区| 老色鬼永久精品网站| 5个黑人躁我一个视频| 国产亚洲人成a在线v网站| 寂寞骚妇被后入式爆草抓爆| 好男人日本社区www| 暖暖 免费 高清 日本 在线 | 无码人妻丝袜视频在线播免费| 免费国产污网站在线观看| 久久丫精品系列| 国产亚洲精品一区二区三区| 亚洲日本va午夜在线电影| 青草影院内射中出高潮-百度| a v 在线视频 亚洲免费| 亚洲成av人影院无码不卡| 农村老熟妇乱子伦视频| 欧美老熟妇牲交| 国产成人无码国产亚洲| 欧洲一卡2卡3卡4卡国产| 成人综合网亚洲伊人| 国产精品va在线播放| 亚洲成a人片在线观看无码专区| 国产偷亚洲偷欧美偷精品| 亚洲欧美一区二区三区在线| 久青草国产97香蕉在线影院| 亚洲成a人片在线观看天堂| 伊人久久亚洲综合影院首页| 亚洲 欧美 变态 另类 综合| 日韩精品区一区二区三vr| 亚洲中文字幕丝祙制服| 亚洲欧美成人久久一区| 国产熟妇乱子伦视频在线观看| 色噜噜一区二区三区| 久久久久国产一区二区| 狠人干练合综合网| 国产97色在线 | 欧洲| 亚洲日本va中文字幕久久| 人妻被按摩师玩弄到潮喷| 满春阁精品a∨在线观看|