在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP3K9 Antibody

MAP3K9 Antibody

  • 中文名稱：
    MAP3K9兔多克隆抗體
  • 貨號：
    CSB-PA013434LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Rat lung tissue
      All lanes: MAP3K9 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 122, 124 kDa
      Observed band size: 122 kDa
    • IHC image of CSB-PA013434LA01HU diluted at 1:400 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA013434LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAP3K9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MAP3K9
  • 別名：
    M3K9_HUMAN antibody; Map3k9 antibody; MEKK9 antibody; Mitogen activated protein kinase kinase kinase 9 antibody; Mitogen-activated protein kinase kinase kinase 9 antibody; Mixed lineage kinase 1 (tyr and ser/thr specificity) antibody; Mixed lineage kinase 1 antibody; MLK1 antibody; PRKE1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase kinase kinase 9 protein (864-1098AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MAP3K9 Antibody (CSB-PA013434LA01HU)，的標記方式是Non-conjugated。對于MAP3K9 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA013434LB01HU MAP3K9 Antibody, HRP conjugated ELISA
    FITC CSB-PA013434LC01HU MAP3K9 Antibody, FITC conjugated
    Biotin CSB-PA013434LD01HU MAP3K9 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:100-1:500
    IF 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
  • 基因功能參考文獻：
    1. Data report that MKL1 was both sufficient and necessary for p65-dependent pro-inflammatory transcriptional program. MKL1 deficiency erased key histone modifications synonymous with transactivation on p65 target promoters. Specifically, MKL1 defined histone H3K4 trimethylation landscape for NF-kappaB dependent transcription. PMID: 28298643
    2. There was a negatively relationship between miR-15a and MAP3K9 expression in NP cells. PMID: 28081468
    3. miR148b directly targeted mitogenactivated protein kinase (MAPK) kinase kinase 9 (MAP3K9), an upstream activator of MAPK kinase/cJun Nterminal kinase (JNK) signaling, suppressing the protein but not the mRNA levels. PMID: 26573018
    4. identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation PMID: 23836671
    5. estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway PMID: 19826002

    顯示更多

    收起更多

  • 相關疾病：
    May play a role in esophageal cancer susceptibility and/or development.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性：
    Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
  • 數據庫鏈接：

    HGNC: 6861

    OMIM: 600136

    KEGG: hsa:4293

    STRING: 9606.ENSP00000451263

    UniGene: Hs.445496



主站蜘蛛池模板： 99久久伊人精品综合观看| 中文 在线 日韩 亚洲 欧美| 国产真人无码作爱视频免费| 国产aⅴ爽av久久久久久| 最近最好的中文字幕2019免费| 午夜成人理论无码电影在线播放| 亚洲熟悉妇女xxx妇女av| 亚洲日韩高清在线亚洲专区| 国产高清视频在线观看97| 精品无码国产自产拍在线观看| 无码乱人伦一区二区亚洲一| 少妇午夜福利一区二区| 天天躁夜夜躁天干天干2020| 中国china露脸自拍性hd| 特级毛片爽www免费版| 亚洲欧美日韩国产综合在线一区 | 国产婷婷亚洲999精品小说| 黑人巨大av无码专区| 免费无码又爽又高潮视频| 又黄又爽又色视频免费| 国产精品美女久久久久久2021| 精品久久久久久中文字幕202| 成人综合伊人五月婷久久| 内射干少妇亚洲69xxx| 国产欧美在线一区二区三| 欧美性受xxxxzooz乱毛| 内射后入在线观看一区| 久久精品亚洲一区二区三区浴池| 日本一区二区三区免费播放视频站| 国内极度色诱视频网站| 欧美人与动性xxxxx杂| 久久精品国产99久久香蕉| 大ji巴好深好爽又大又粗视频| 午夜视频在线瓜伦| 自愉自愉产区二十四区| 国产精品女人呻吟在线观看| 中文字幕久热精品视频在线| 国产无套内射久久久国产| 亚洲欧美日韩综合久久| 久久精品人人做人人爱爱漫画 | 亚洲人成网站在线播放小说|