在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP3K12 Antibody

MAP3K12 Antibody

  • 中文名稱：
    MAP3K12兔多克隆抗體
  • 貨號(hào)：
    CSB-PA858409
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA858409(MAP3K12 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA858409(MAP3K12 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Dlk antibody; Dual leucine zipper bearing kinase antibody; Dual leucine zipper kinase DLK antibody; Leucine-zipper protein kinase antibody; M3K12_HUMAN antibody; Map3k12 antibody; MAPK-upstream kinase antibody; MEKK12 antibody; Mitogen-activated protein kinase kinase kinase 12 antibody; Mixed lineage kinase antibody; MUK antibody; Protein kinase MUK antibody; ZPK antibody; ZPKP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human MAP3K12
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
  • 基因功能參考文獻(xiàn)：
    1. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. PMID: 28641113
    2. REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase PMID: 27100796
    3. miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. PMID: 25999017
    4. Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration. PMID: 25341110
    5. these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins. PMID: 21893036
    6. The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK expression and the clinical course of the disease. PMID: 21526495
    7. the DLK-ERK signaling pathway may act as a regulator of the interaction that occurs between Hsp27 and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function PMID: 19675578
    8. for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity PMID: 14697235
    9. ZIPK is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity. PMID: 15611134
    10. DLK is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification PMID: 15695824
    11. DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression. PMID: 18995835
    12. Src-dependent tyrosine phosphorylation recombinant human DLK was important for regulation of its activity. DLK may have a role in PDGF signaling. PMID: 19146952

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性：
    Highly expressed in brain and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6851

    OMIM: 600447

    KEGG: hsa:7786

    STRING: 9606.ENSP00000448689

    UniGene: Hs.713539



主站蜘蛛池模板： 无遮挡很爽很污很黄的网站| 国产福利姬喷水福利在线观看| 无码国模大尺度视频在线观看 | 久久精品女人的天堂av| 五月综合缴情婷婷六月| 99国精品午夜福利视频不卡| 人妻丰满熟妇av无码区免| 精品丝袜人妻久久久久久| 国产精品国产午夜免费看福利| 欧美xxxx做受欧美人妖| 天天躁日日躁狠狠躁av麻豆| 一本色道久久综合狠狠躁| 久久视频在线视频精品| 成年美女黄网站18禁免费| 国产成人综合久久免费| 久久久精品日本一区二区三区| 成人动漫在线观看| 国产自偷在线拍精品热| 波多野结av在线无码中文| 精品久久综合1区2区3区激情| 色偷偷色噜噜狠狠成人免费视频| 欧美巨波霸乳影院| 免费现黄频在线观看国产| 无码日韩精品一区二区三区免费 | 2020最新无码福利视频| 337p日本欧洲亚洲大胆精筑| 亚洲欧美国产精品专区久久| 亚洲中文无码a∨在线观看| 动漫成人无码精品一区二区三区| 国产精品久久久久久52avav| 中文字幕乱码免费看电影| 亚洲精品国产成人精品| 人人妻碰人人免费| www夜片内射视频在观看视频| 国产精品无码无在线观看| 亚洲成a人片在线播放| 久久精品亚洲中文字幕无码麻豆| 午夜精品久久久久久久无码| 久久精品国产99久久香蕉| 成人无遮挡18禁免费视频| 亚洲精品乱码久久久久久v |