在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP3K12 Antibody, Biotin conjugated

MAP3K12 Antibody, Biotin conjugated

  • 中文名稱：
    MAP3K12兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA013420LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAP3K12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Dlk antibody; Dual leucine zipper bearing kinase antibody; Dual leucine zipper kinase DLK antibody; Leucine-zipper protein kinase antibody; M3K12_HUMAN antibody; Map3k12 antibody; MAPK-upstream kinase antibody; MEKK12 antibody; Mitogen-activated protein kinase kinase kinase 12 antibody; Mixed lineage kinase antibody; MUK antibody; Protein kinase MUK antibody; ZPK antibody; ZPKP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase kinase kinase 12 protein (101-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
  • 基因功能參考文獻：
    1. LZK cooperates with DLK to promote retinal ganglion cell death in response to axon injury. PMID: 28641113
    2. REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase PMID: 27100796
    3. miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. PMID: 25999017
    4. Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration. PMID: 25341110
    5. these findings indicate that DLK participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins. PMID: 21893036
    6. The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK expression and the clinical course of the disease. PMID: 21526495
    7. the DLK-ERK signaling pathway may act as a regulator of the interaction that occurs between Hsp27 and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function PMID: 19675578
    8. for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity PMID: 14697235
    9. ZIPK is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity. PMID: 15611134
    10. DLK is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification PMID: 15695824
    11. DAPK-ZIPK-L13a axis forms a unique regulatory module that first represses, then repermits inflammatory gene expression. PMID: 18995835
    12. Src-dependent tyrosine phosphorylation recombinant human DLK was important for regulation of its activity. DLK may have a role in PDGF signaling. PMID: 19146952

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性：
    Highly expressed in brain and kidney.
  • 數據庫鏈接：

    HGNC: 6851

    OMIM: 600447

    KEGG: hsa:7786

    STRING: 9606.ENSP00000448689

    UniGene: Hs.713539



主站蜘蛛池模板： 亚洲国产制服丝袜高清在线| 国产精品国产三级欧美二区| 免费国产黄网在线观看| av永久天堂一区| 亚洲男女一区二区三区| 日本肥老妇色xxxxx日本老妇| 成年无码av片| 一二三四视频社区在线| 成人亚洲精品久久99狠狠| 亚洲国产成人精品无码区四虎| 欧美午夜精品一区二区蜜桃| 国产精品毛片va一区二区三区 | 99久久久无码国产精品动漫| 久久精品国产只有精品66| 在线视频观看免费视频18| 无码av波多野结衣久久| 无码人妻丰满熟妇区免费| 亚洲龙腾成小说人网| 亚洲另类欧美综合久久图片区 | 欧美熟妇另类久久久久久不卡| av淘宝国产在线观看| 亚洲国产综合av在线观看| 成 人影片 免费观看在线| 久久精品水蜜桃av综合天堂| 亚洲国产精品无码一线岛国| 狠狠cao2020高清视频| 蜜臀视频一区二区在线播放| 亚洲最大成人网站| 亚洲精品久久久久久动漫器材一区| 久久亚洲精品成人无码网站夜色| 粗大猛烈进出高潮视频| 夜夜嗨av一区二区三区| 亚洲一区二区无码偷拍| 成人av片在线观看免费| 国产国语亲子伦亲子| 国产成人免费爽爽爽视频| 国产办公室无码视频在线观看| 国产乱子伦60女人的皮视频| 亚洲精品久久久久久久久久吃药| 永久免费看啪啪的网站| 国产精品高潮呻吟av久久男男|