在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAK Antibody

  • 中文名稱:
    MAK兔多克隆抗體
  • 貨號:
    CSB-PA013369GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    MAK
  • 別名:
    MAKSerine/threonine-protein kinase MAK antibody; EC 2.7.11.1 antibody; Male germ cell-associated kinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human MAK
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
  • 基因功能參考文獻:
    1. We report the first case of leaking intraretinal cystoid spaces due to mutation in MAK. Mak regulates microtubule stability via phosphorylating RP1. Abnormal Mak may impact retinal photoreceptor ciliary length and subcompartmentalization. PMID: 26894652
    2. One patient was homozygous for the insertion, one compound heterozygous with a missense change on the other allele (c. 46G>A; p.Gly16Arg), and three were heterozygous carriers. PMID: 26558903
    3. We identified the MAK and DHDDS mutations homozygously in only 2.1% and 0.8%, respectively, of patients of mixed ethnicity, but in 25.7% and 8.6%, respectively, of cases reporting Jewish ancestry PMID: 25255364
    4. Nonsense and missense mutations in MAK give rise to a non-syndromic recessive RP phenotype without apparent extra-ocular features. PMID: 25385675
    5. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    6. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    7. these data implicate MAK in both adrogen receptor activation and chromosomal instability, acting in both early and late prostate cancer development. PMID: 21986944
    8. The patterns of disease expression in the MAK form of arRP showed some resemblance to patterns described in autosomal dominant RP, especially the form caused by RP1 mutations. PMID: 22110072
    9. Exome sequencing to identify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase (MAK) as the cause of disease in an isolated individual with retinitis pigmentosa. PMID: 21825139
    10. Exome sequencing combined with this approach identified a homozygous nonsense mutation in male germ cell-associated kinase (MAK) in the single affected member of a consanguineous Turkish family with retinitis pigmentosa. PMID: 21835304
    11. identification and transcriptional activation by androgen in prostate cancer cells PMID: 12084720
    12. MAK plays a general role in androgen receptor(AR) function in prostate cancer cells and is likely to be a general coactivator of AR in prostate tissues. PMID: 16951154
    13. MRK phosphorylates Scythe at T1080 in vitro as determined by site-directed mutagenesis and mass spectrometry, supporting the consensus and suggesting Scythe as a physiological substrate for MRK. PMID: 16954377

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 62 (RP62)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photo
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6816

    OMIM: 154235

    KEGG: hsa:4117

    STRING: 9606.ENSP00000313021

    UniGene: Hs.446125



主站蜘蛛池模板: 久久99精品久久久久久齐齐| 少妇人妻丰满做爰xxx| 好疼太大了太粗太长了视频| 2020最新无码国产在线观看| 伦理片无码电影在线看| 国产成人a无码短视频| 曰批免费视频播放免费| 国产熟妇高潮叫床视频播放| 99在线精品视频在线观看| 中文国产成人精品久久久| 在线看片国产日韩欧美亚洲| 99久久亚洲精品日本无码| 一本大道av伊人久久综合| 成人欧美一区二区三区在线| 亚洲性无码av在线| 精品少妇无码一区二区三批| 午夜天堂一区人妻| 性色av免费观看| 欧美老妇牲交videos| 亚洲精品国产一区二区精华| 国产精品调教视频一区| 无码丰满少妇2在线观看| 国产精品va在线观看无码| 国产jjzzjjzz视频全部免费| 久久天天躁狠狠躁夜夜躁2012| 亚洲蜜芽在线精品一区| 天堂在线中文| 熟妇人妻av无码一区二区三区| 亚洲看片lutube在线观看| 亚洲无人区午夜福利码高清完整版 | 丰满人妻无奈张开双腿av| 俺去俺来也www色官网| 蜜臀精品无码av在线播放| 久久99精品国产.久久久久| 少妇被爽到高潮在线观看| 国产欧美亚洲精品a第一页| 午夜理理伦电影a片无码| 午夜片神马影院福利| 国产白嫩护士在线播放| 欧美在线精彩视频免费播放| 少妇人妻偷人精品视蜜桃|