在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAK Antibody, FITC conjugated

  • 中文名稱:
    MAK兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA013369LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MAK
  • 別名:
    MAKSerine/threonine-protein kinase MAK antibody; EC 2.7.11.1 antibody; Male germ cell-associated kinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase MAK protein (200-440AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.
  • 基因功能參考文獻:
    1. We report the first case of leaking intraretinal cystoid spaces due to mutation in MAK. Mak regulates microtubule stability via phosphorylating RP1. Abnormal Mak may impact retinal photoreceptor ciliary length and subcompartmentalization. PMID: 26894652
    2. One patient was homozygous for the insertion, one compound heterozygous with a missense change on the other allele (c. 46G>A; p.Gly16Arg), and three were heterozygous carriers. PMID: 26558903
    3. We identified the MAK and DHDDS mutations homozygously in only 2.1% and 0.8%, respectively, of patients of mixed ethnicity, but in 25.7% and 8.6%, respectively, of cases reporting Jewish ancestry PMID: 25255364
    4. Nonsense and missense mutations in MAK give rise to a non-syndromic recessive RP phenotype without apparent extra-ocular features. PMID: 25385675
    5. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    6. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    7. these data implicate MAK in both adrogen receptor activation and chromosomal instability, acting in both early and late prostate cancer development. PMID: 21986944
    8. The patterns of disease expression in the MAK form of arRP showed some resemblance to patterns described in autosomal dominant RP, especially the form caused by RP1 mutations. PMID: 22110072
    9. Exome sequencing to identify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase (MAK) as the cause of disease in an isolated individual with retinitis pigmentosa. PMID: 21825139
    10. Exome sequencing combined with this approach identified a homozygous nonsense mutation in male germ cell-associated kinase (MAK) in the single affected member of a consanguineous Turkish family with retinitis pigmentosa. PMID: 21835304
    11. identification and transcriptional activation by androgen in prostate cancer cells PMID: 12084720
    12. MAK plays a general role in androgen receptor(AR) function in prostate cancer cells and is likely to be a general coactivator of AR in prostate tissues. PMID: 16951154
    13. MRK phosphorylates Scythe at T1080 in vitro as determined by site-directed mutagenesis and mass spectrometry, supporting the consensus and suggesting Scythe as a physiological substrate for MRK. PMID: 16954377

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 62 (RP62)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
  • 蛋白家族:
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 組織特異性:
    Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photo
  • 數據庫鏈接:

    HGNC: 6816

    OMIM: 154235

    KEGG: hsa:4117

    STRING: 9606.ENSP00000313021

    UniGene: Hs.446125



主站蜘蛛池模板: 国产精品人妻熟女男人的天堂| 国产影片av级毛片特别刺激| 最近中文字幕免费mv在线| 色偷偷偷久久伊人大杳蕉| 99精品国产一区二区三区不卡 | 人人做人人爽人人爱| 国产午夜鲁丝无码拍拍| 岛国av无码免费无禁网站麦芽| 在线视频免费无码专区| 亚洲嫩模喷白浆在线观看| 国产高清无密码一区二区三区 | 真人抽搐一进一出视频| 天天噜噜噜在线视频| 九九影院午夜理论片少妇| 隔壁人妻被水电工征服 | 影音先锋男人av鲁色资源网| 天天天欲色欲色www免费| 四虎国产精亚洲一区久久特色| 欧美性猛交xxxx三人| 国产成人久久777777| 人妻体体内射精一区二区| 人妻丰满熟妇无码区免费| 2020精品国产视| 国产免费不卡av在线播放| 午夜亚洲福利在线老司机| 噜噜噜亚洲色成人网站| 久久九九精品国产综合喷水| 未满十八18禁止午夜免费网站 | 一二三四在线视频社区3| 女人被弄到高潮的免费视频| 女同免费毛片在线播放| 日亚韩在线无码一区二区三区| 免费吃奶摸下激烈视频| 尤物yw193无码点击进入| 国产av无码专区亚洲草草| 无码日韩做暖暖大全免费不卡| 特大巨黑吊xxxx高潮| 亚洲337少妇裸体艺术| 偷自拍亚洲视频在线观看99| 日日碰狠狠添天天爽无码| 中文精品无码中文字幕无码专区|