在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAGEL2 Antibody

MAGEL2 Antibody

Unavailable
  • 中文名稱：
    MAGEL2兔多克隆抗體
  • 貨號：
    CSB-PA013771
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA013771(MAGEL2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MAGEL2
  • 別名：
    MAGEL2 antibody; NDNL1 antibody; MAGE-like protein 2 antibody; Necdin-like protein 1 antibody; Protein nM15 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MAGEL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK.
  • 基因功能參考文獻：
    1. the single-nucleotide polymorphism rs850807, which is putatively functional and linked with MAGEL2 and NDN Genetic variation in rs850807 was strongly and exclusively associated with the ideas of reference subscale of the schizophrenia spectrum, which is best typified as paranoia PMID: 29343559
    2. Genes encoding MAGEL2 partners, either in the retrograde transport or in the ubiquitination-deubiquitination complexes, are promising candidates as Opitz trigonocephaly C syndrome -causing genes. PMID: 28281571
    3. We report on first two unrelated patients of Polish descent with Schaaf-Yang syndrome caused by de-novo intragenic mutations in the MAGEL2 gene, identified by next-generation sequencing PMID: 29389715
    4. This study provides strong evidence for the pathogenicity of truncating mutations of the paternal allele of MAGEL2, refines the associated clinical phenotypes, and highlights implications for genetic counseling for affected families PMID: 27195816
    5. A similar progressive loss of leptin sensitivity caused by loss of MAGEL2 in children with Prader-Willi syndrome could explain the delayed onset of increased appetite and weight gain in this complex disorder. PMID: 25926624
    6. Truncating Mutations of MAGEL2, a Gene within the Prader-Willi Locus, Are Responsible for Severe Arthrogryposis. PMID: 26365340
    7. MAGEL2 is a new gene causing complex autism spectrum disorder and MAGEL2 loss of function can contribute to several aspects of the Prader-Willi syndrome phenotype. PMID: 24076603
    8. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. PMID: 23452853
    9. Results suggest that MAGEL2 may not play a role in the pathophysiology of schizophrenia and mood disorders in the Japanese population. PMID: 20467835
    10. MAGEL2 gene is imprinted, with preferential expression from the paternal allele. PMID: 10556298

    顯示更多

    收起更多

  • 相關疾病：
    Schaaf-Yang syndrome (SHFYNG)
  • 亞細胞定位：
    Early endosome. Cytoplasm. Nucleus.
  • 組織特異性：
    Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.
  • 數據庫鏈接：

    HGNC: 6814

    OMIM: 605283

    KEGG: hsa:54551

    STRING: 9606.ENSP00000433433

    UniGene: Hs.141496



主站蜘蛛池模板： 国产美女精品视频线免费播放 | 欧美亚洲日韩国产人成在线播放| 久久久中文字幕日本无吗| 中文字幕人妻av一区二区| 欲妇荡岳丰满少妇岳| 国产精品国产三级国快看| 欧美mv日韩mv国产网站app| 国产在线观看超清无码视频一区二区| 欧美日韩国产专区一区二区| 亚洲精品无播放器在线播放| 亚洲 精品 综合 精品 自拍| 十八禁真人啪啪免费网站| 国产成人午夜在线视频a站| 国产精品免费福利久久| 色偷偷av男人的天堂| 国产精品主播一区二区三区| 国产精品人妻熟女男人的天堂| 色www视频永久免费| 久久国产劲暴∨内射新川| 久久国产精品国产四虎90后| 久久久久久久久久久综合日本| 丰满人妻妇伦又伦精品国产| 国产精品无码专区久久久| 国产乱人伦av在线麻豆a | 精品爆乳一区二区三区无码av| 亚洲熟妇无码av不卡在线观看| 18禁超污无遮挡无码免费动态图| 国产真实乱对白精彩久久老熟妇女| 无码国产午夜福利片在线观看| 色婷婷亚洲精品综合影院| 日韩电影一区二区三区| 亚洲妇女无套内射精| 国产精品一国产精品一k频道 | 亚洲国产精品成人精品无码区| 亚洲精品午夜国产va久久成人 | 亚洲欧洲日本无在线码| 精品国产肉丝袜久久| 久久精品国产精品亚洲艾草网| 99久久久无码国产精品试看| 亚洲国产日韩一区三区| 日日鲁鲁鲁夜夜爽爽狠狠视频97|