在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAGEL2 Antibody

MAGEL2 Antibody

  • 中文名稱：
    MAGEL2兔多克隆抗體
  • 貨號：
    CSB-PA277591
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA277591(MAGEL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MAGEL2
  • 別名：
    MAGEL2 antibody; NDNL1 antibody; MAGE-like protein 2 antibody; Necdin-like protein 1 antibody; Protein nM15 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MAGEL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK.
  • 基因功能參考文獻：
    1. the single-nucleotide polymorphism rs850807, which is putatively functional and linked with MAGEL2 and NDN Genetic variation in rs850807 was strongly and exclusively associated with the ideas of reference subscale of the schizophrenia spectrum, which is best typified as paranoia PMID: 29343559
    2. Genes encoding MAGEL2 partners, either in the retrograde transport or in the ubiquitination-deubiquitination complexes, are promising candidates as Opitz trigonocephaly C syndrome -causing genes. PMID: 28281571
    3. We report on first two unrelated patients of Polish descent with Schaaf-Yang syndrome caused by de-novo intragenic mutations in the MAGEL2 gene, identified by next-generation sequencing PMID: 29389715
    4. This study provides strong evidence for the pathogenicity of truncating mutations of the paternal allele of MAGEL2, refines the associated clinical phenotypes, and highlights implications for genetic counseling for affected families PMID: 27195816
    5. A similar progressive loss of leptin sensitivity caused by loss of MAGEL2 in children with Prader-Willi syndrome could explain the delayed onset of increased appetite and weight gain in this complex disorder. PMID: 25926624
    6. Truncating Mutations of MAGEL2, a Gene within the Prader-Willi Locus, Are Responsible for Severe Arthrogryposis. PMID: 26365340
    7. MAGEL2 is a new gene causing complex autism spectrum disorder and MAGEL2 loss of function can contribute to several aspects of the Prader-Willi syndrome phenotype. PMID: 24076603
    8. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. PMID: 23452853
    9. Results suggest that MAGEL2 may not play a role in the pathophysiology of schizophrenia and mood disorders in the Japanese population. PMID: 20467835
    10. MAGEL2 gene is imprinted, with preferential expression from the paternal allele. PMID: 10556298

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Schaaf-Yang syndrome (SHFYNG)
  • 亞細胞定位：
    Early endosome. Cytoplasm. Nucleus.
  • 組織特異性：
    Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient.
  • 數據庫鏈接：

    HGNC: 6814

    OMIM: 605283

    KEGG: hsa:54551

    STRING: 9606.ENSP00000433433

    UniGene: Hs.141496



主站蜘蛛池模板： 强奷乱码中文字幕熟女一| 国产久热精品无码激情| 人禽无码视频在线观看| 日韩 欧美 国产 一区三| 人人妻人人澡人人爽欧美一区九九| 在线 | 麻豆国产传媒61国产免费 视频在线+欧美十亚洲曰本 | 亚洲中文字幕av无码区| 男人和女人高潮做爰视频| 亚洲伊人久久精品酒店| 免免费国产aaaaa片| 国产又粗又猛又黄又爽无遮挡| 国产精品xxx在线| 久久综合丝袜日本网| 亚洲中文字幕av不卡无码| 久久人人爽人人爽爽久久小说| 国产精品毛片在线完整版sab| 一本久久知道综合久久| 精品人伦一区二区三区蜜桃免费| 99久久久无码国产精品秋霞网| 精品久久国产综合婷婷五月| 亚洲色欲av无码成人专区| 久久久免费无码成人影片| 少妇下面好紧好多水真爽播放| 成 人 在 线 免费观看| 免费无人区男男码卡二卡| 鲁一鲁一鲁一鲁一曰综合网| 真正免费毛片在线播放| 毛片无码一区二区三区a片视频| 亚洲欧美日韩中文字幕在线一区| 久久久久四虎精品免费入口| 人妻换人妻a片爽麻豆| 三级4级全黄60分钟| 人人超碰人摸人爱| 综合自拍亚洲综合图区欧美| av无码国产在线看免费网站| 插b内射18免费视频| 精品国产乱码久久久久夜深人妻| 欧美精品欧美人与动人物牲交| 亚洲综合色在线观看一区| 国产裸体xxxx视频| 亚洲综合无码精品一区二区三区|