在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAGEC2 Antibody

  • 中文名稱:
    MAGEC2兔多克隆抗體
  • 貨號:
    CSB-PA013349GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cancer testis antigen 10 antibody; Cancer/testis antigen 10 antibody; CT10 antibody; HCA587 antibody; Hepatocellular cancer antigen 587 antibody; Hepatocellular carcinoma associated antigen 587 antibody; Hepatocellular carcinoma-associated antigen 587 antibody; MAGC2_HUMAN antibody; MAGE C2 antigen antibody; MAGE E1 antigen antibody; MAGE family member C2 antibody; MAGE-C2 antigen antibody; MAGE-E1 antigen antibody; MAGEC2 antibody; Melanoma antigen family C 2 antibody; Melanoma antigen family C2 antibody; Melanoma antigen family E 1 cancer/testis specific antibody; Melanoma associated antigen C2 antibody; Melanoma-associated antigen C2 antibody; MGC13377 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human MAGEC2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
  • 基因功能參考文獻:
    1. HCA587/MAGEC2 directly binds TAF9 via its CR domain, suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA to regulate certain genes transcription. PMID: 29257297
    2. our findings revealed a previously unrecognized regulation of STAT3 activation in tumor cells by cancer/testis antigen MAGEC2, and provided a molecular mechanism for the oncogenic activity of MAGEC2 in cancer cells. PMID: 27775077
    3. High MAGE-C2 expression was found in 38.18% of triple negative breast cancer tissues and in 9.09% of adjacent tissues. High MAGE-C2 expression in TNBC patients was closely associated with tumor node metastasis and shorter survival time. PMID: 27843173
    4. our study provides a suitable cell model for exploring the biological functions of MAGEC2 in malignant cells, and sheds light on the molecular pathway by which MAGEC2 promotes tumor development. PMID: 27636589
    5. The expressions of MAGE-C2 mRNA and MAGE-C2 protein were closely associated with stage, metastasis of lung cancer. PMID: 26903162
    6. In gastrointestinal stromal tumors, 5/51 (10%) patients expressed MAGE-C2. High-grade GIST are more likely to express MAGE-C2. MAGE-C2 also significantly correlates with mitotic rate and tumor size. PMID: 24713551
    7. Our results indicate that MAGEC2 has a role in breast cancer metastasis through inducing epithelial-mesenchymal transition PMID: 24687377
    8. overexpression of HCA587 resulted in a significant enhancement of LMP1-induced IL-6 production. These data indicate that HCA587 is a new negative regulator of BS69 PMID: 24866244
    9. MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. PMID: 23096706
    10. Cytotoxic T cell clones directed against MAGE-C2 peptides recognize EB81-melanoma tumor cells treated with interferon (IotaFN)-gamma. PMID: 22925930
    11. MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy. PMID: 21754986
    12. MAGEC2 is a sensitive and novel marker for seminoma. PMID: 21780320
    13. p43-57 is the first HCA587-derived major histocompatibility complex class II-restricted epitope to fulfil all prerequisites for use as a peptide vaccine in patients with HCA587-expressing tumors PMID: 21595801
    14. HCA 587 may be a valuable target antigen for diagnosis and vaccination of hepatocelular carcinoma patients. PMID: 12920247
    15. identified 2 antigens encoded by gene MAGE-C2 which are recognized by several melanoma-specific cytolytic T lymphocyte clones isolated from a melanoma patient; both antigens are presented by HLA-A2 PMID: 14999777
    16. CT10 expression was more frequently found in squamous cell carcinoma than in adenocarcinoma. PMID: 15061963
    17. because of the expression pattern of gene MAGE-C2, this new antigen is strictly tumor-specific PMID: 17096150
    18. the MAGE-A3 and MAGE-C2 gene promoter regions are de-methylated in the presence of activated KIT but become methylated on inhibition of KIT, consistent with the downregulation of mRNA and protein PMID: 17495964
    19. MAGE-C2/CT-10 is expressed in hepatocellular carcinoma PMID: 18942708

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
  • 組織特異性:
    Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung c
  • 數據庫鏈接:

    HGNC: 13574

    OMIM: 300468

    KEGG: hsa:51438

    STRING: 9606.ENSP00000354660

    UniGene: Hs.123536



主站蜘蛛池模板: 国产又色又爽又黄的在线观看视频| 无码一区二区三区在线| 少妇做爰免费视频了| 波多野42部无码喷潮| 成年轻人电影免费无码| 国产精品18久久久久久欧美| 浪潮av激情高潮国产精品| 亚洲欧美一区二区成人片| 亚洲国内精品自在线影院| 成人看片黄a免费看| 国精产品一品二品国精在线观看| 婷婷亚洲久悠悠色悠在线播放| 女人张开双腿让男人猛桶| 尤物蜜芽国产成人精品区| 亚洲精品无播放器在线播放| 中文在线а天堂中文在线新版| 亚洲中文字幕乱码av波多ji| 亚洲不卡1卡2卡三卡入口| 真实的国产乱xxxx| 国产一区二区内射最近更新| 久久久成人精品av四区| av国産精品毛片一区二区网站| 国产1卡2卡三卡四卡精品| 日韩一区二区a片免费观看| 少妇午夜啪爽嗷嗷叫视频| 亚洲精品tv久久久久久久久j | 久久不见久久见www免费| 50岁熟妇的呻吟声对白| 欧美亚洲国产一区二区三区| 欧美成人免费全部| 日本一区二区无卡高清视频| 国产麻无矿码直接观看| 国产成人无码区免费内射一片色欲| 激情综合亚洲色婷婷五月| 亚洲自偷自拍另类小说| 日产精品一区二区| 国产成人福利美女观看视频| 日本高清色本在线www| 欧美牲交a欧美牲交aⅴ免费真| 亚洲vs日韩vs欧美vs久久| 国产成人午夜无码电影在线观看|