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  4. MAEL Antibody

MAEL Antibody

  • 中文名稱：
    MAEL兔多克隆抗體
  • 貨號：
    CSB-PA842695LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA842695LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA842695LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAEL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MAEL
  • 別名：
    cancer/testis antigen 128 antibody; CT128 antibody; FLJ14904 antibody; mael antibody; MAEL_HUMAN antibody; maelstrom homolog (Drosophila) antibody; Maelstrom homolog antibody; OTTHUMP00000032344 antibody; Protein maelstrom homolog antibody; RP11-102C16.1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein maelstrom homolog protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MAEL Antibody (CSB-PA842695LA01HU)，的標記方式是Non-conjugated。對于MAEL Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA842695LB01HU MAEL Antibody, HRP conjugated ELISA
    FITC CSB-PA842695LC01HU MAEL Antibody, FITC conjugated
    Biotin CSB-PA842695LD01HU MAEL Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.
  • 基因功能參考文獻：
    1. MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis PMID: 29095993
    2. Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence. PMID: 27926513
    3. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1. PMID: 27181205
    4. Study demonstrated that MAEL interacts with Snail and inhibit E-cadherin promoter activity. MAEL is an oncogene that plays an important role in the development and progression of colon cancer. PMID: 27537253
    5. Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs. PMID: 24189637
    6. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3beta/Snail signaling. PMID: 23929794
    7. These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation. PMID: 19693694

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Maelstrom family
  • 組織特異性：
    Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
  • 數據庫鏈接：

    HGNC: 25929

    OMIM: 611368

    KEGG: hsa:84944

    STRING: 9606.ENSP00000356846

    UniGene: Hs.651245



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