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  4. LZTFL1 Antibody

LZTFL1 Antibody

  • 中文名稱：
    LZTFL1兔多克隆抗體
  • 貨號：
    CSB-PA568879
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA568879(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA568879(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human testis tissue, 293T cells, A172 cells, Primary antibody: CSB-PA568879(LZTFL1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LZTFL1
  • 別名：
    5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human LZTFL1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
  • 基因功能參考文獻：
    1. LZTFL1 inhibits lung tumorigenesis PMID: 26364604
    2. these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
    3. LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
    4. This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
    5. The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
    6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
    7. LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871

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  • 相關疾病：
    Bardet-Biedl syndrome 17 (BBS17)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    LZTFL1 family
  • 組織特異性：
    Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee
  • 數據庫鏈接：

    HGNC: 6741

    OMIM: 606568

    KEGG: hsa:54585

    STRING: 9606.ENSP00000296135

    UniGene: Hs.30824



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