在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LRRK1 Antibody

  • 中文名稱:
    LRRK1兔多克隆抗體
  • 貨號:
    CSB-PA060159
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LRRK1
  • 別名:
    KIAA1790 antibody; Leucine rich repeat serine/threonine protein kinase 1 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; LRRK 1 antibody; Lrrk1 antibody; LRRK1_HUMAN antibody; RIPK6 antibody; Roco1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human LRRK1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. data suggest that LRRK1 variant (rs2924835) and LRRK2 variants (rs34594498, rs34410987, and rs33949390) are not associated with essential tremor in this Han Chinese population PMID: 29812962
    2. LRRK1 plays a critical role in the regulation of bone mass in humans. PMID: 27055475
    3. A novel LRRK1 mutation has been identified in two siblings in an Indian family with osteosclerotic metaphyseal dysplasia. PMID: 27829680
    4. We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR-containing endosomes. PMID: 25413345
    5. LRRK1 carries out distinct functions from LRRK2 by interacting with different cellular proteins. PMID: 24947832
    6. LRRK1 mutations may have a role in Parkinson's disease PMID: 24241507
    7. The function of LRRK1 and both the physiological and the pathological roles of LRRK2 are only beginning to unfold. PMID: 22988872
    8. purified and active LRRK1 and LRRK2 can form dimers in their full-length conformation PMID: 22952686
    9. feedback down-regulation of LRRK1 kinase activity by EGFR plays an important role in the appropriate endosomal trafficking of EGFR PMID: 22337768
    10. We report the molecular characterization of human LRRK1 and show for the first time that LRRK1 is a functional protein kinase and a GDP/GTP-binding protein. We propose a model in which LRRK1 cycles between a GTP-bound active and a GDP-bound inactive state PMID: 16243488
    11. Comparison of evolutionary interspecies sequences of LRRK1 and LRRK2 suggests they diverged from a common founder gene implicated in Parkinson disease. PMID: 17225181
    12. Two rare coding variants ss65713826 and ss65713830 were more frequent in patients than controls in norwegain Parkinson's disease. PMID: 17324517
    13. mutations in LRRK2 are more prone to form inclusion bodies in transfected cells and are more toxic than equivalent mutations in LRRK1 PMID: 17394548
    14. LRRK1 genes encode low levels of expressed mRNA corresponding to low levels of protein during development. PMID: 18045479
    15. LRRK1 are active in the adult human cortex cerebri, hippocampus and also seen in the young human thymus. PMID: 18272292
    16. LRRK1 binds GTP and GDP via its Roc domain and autophosphorylation activity is selectively triggered by GTP. Kinase activity was decreased following introduction of mutations homologous to those of LRRK2 that have been associated with Parkinson's disease. PMID: 16243488

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
  • 數據庫鏈接:

    HGNC: 18608

    OMIM: 610986

    KEGG: hsa:79705

    STRING: 9606.ENSP00000373600

    UniGene: Hs.407918



主站蜘蛛池模板: 狠狠色噜噜狠狠狠狠888奇禾| 国产精品爽爽v在线观看无码| 中文无码av一区二区三区| 新狼窝色av性久久久久久| 亚洲成a×人片在线观看| 粗大的内捧猛烈进出看视频| 成人乱码一区二区三区av| 熟妇女人妻丰满少妇中文字幕| 亚洲卡1卡2卡新区网站| 国产清纯美女遭强到高潮| 午夜精品一区二区三区在线视 | 亚洲欧美日韩成人一区| 欧美人与动交视频在线观看| 日日碰狠狠躁久久躁9| 亚洲色丰满少妇高潮18p| 无码人妻一区二区三区免费| 亚洲gv天堂gv无码男同| 中国少妇videos呻吟| 国产 亚洲 制服 无码 中文| 成人区人妻精品一区二区不卡视频| 国产在热线精品视频99公交| 黑人大战欲求不满人妻| 免费欧洲美女牲交视频| 亚洲人成网站在线播放2019| 亚洲色欲天天天堂色欲网| 色欲天天婬色婬香综合网| 亚洲性啪啪无码av天堂| 人人做人人妻人人精| 伊人久久大香线蕉综合bd高清| 午夜福利92国语| 日本午夜免费福利视频| 精品少妇人妻av久久久| 亚洲综合日韩av无码毛片| 大地资源中文第三页| 久久99国产精品成人| 国产av福利久久| 极品人妻videosss人妻| 少妇大叫太大太粗太爽了a片小说| 成年网站未满十八禁视频天堂| 国产69精品久久久久乱码韩国| 色噜噜av亚洲色一区二区|