在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LRRK1 Antibody, HRP conjugated

  • 中文名稱:
    LRRK1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA655748LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LRRK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LRRK1
  • 別名:
    KIAA1790 antibody; Leucine rich repeat serine/threonine protein kinase 1 antibody; Leucine-rich repeat serine/threonine-protein kinase 1 antibody; LRRK 1 antibody; Lrrk1 antibody; LRRK1_HUMAN antibody; RIPK6 antibody; Roco1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 1 protein (1-68AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. data suggest that LRRK1 variant (rs2924835) and LRRK2 variants (rs34594498, rs34410987, and rs33949390) are not associated with essential tremor in this Han Chinese population PMID: 29812962
    2. LRRK1 plays a critical role in the regulation of bone mass in humans. PMID: 27055475
    3. A novel LRRK1 mutation has been identified in two siblings in an Indian family with osteosclerotic metaphyseal dysplasia. PMID: 27829680
    4. We find that LRRK1-mediated phosphorylation of CLIP-170 causes the accumulation of p150(Glued) (also known as DCTN1) a subunit of dynactin, at microtubule plus ends, thereby facilitating the migration of EGFR-containing endosomes. PMID: 25413345
    5. LRRK1 carries out distinct functions from LRRK2 by interacting with different cellular proteins. PMID: 24947832
    6. LRRK1 mutations may have a role in Parkinson's disease PMID: 24241507
    7. The function of LRRK1 and both the physiological and the pathological roles of LRRK2 are only beginning to unfold. PMID: 22988872
    8. purified and active LRRK1 and LRRK2 can form dimers in their full-length conformation PMID: 22952686
    9. feedback down-regulation of LRRK1 kinase activity by EGFR plays an important role in the appropriate endosomal trafficking of EGFR PMID: 22337768
    10. We report the molecular characterization of human LRRK1 and show for the first time that LRRK1 is a functional protein kinase and a GDP/GTP-binding protein. We propose a model in which LRRK1 cycles between a GTP-bound active and a GDP-bound inactive state PMID: 16243488
    11. Comparison of evolutionary interspecies sequences of LRRK1 and LRRK2 suggests they diverged from a common founder gene implicated in Parkinson disease. PMID: 17225181
    12. Two rare coding variants ss65713826 and ss65713830 were more frequent in patients than controls in norwegain Parkinson's disease. PMID: 17324517
    13. mutations in LRRK2 are more prone to form inclusion bodies in transfected cells and are more toxic than equivalent mutations in LRRK1 PMID: 17394548
    14. LRRK1 genes encode low levels of expressed mRNA corresponding to low levels of protein during development. PMID: 18045479
    15. LRRK1 are active in the adult human cortex cerebri, hippocampus and also seen in the young human thymus. PMID: 18272292
    16. LRRK1 binds GTP and GDP via its Roc domain and autophosphorylation activity is selectively triggered by GTP. Kinase activity was decreased following introduction of mutations homologous to those of LRRK2 that have been associated with Parkinson's disease. PMID: 16243488

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
  • 數據庫鏈接:

    HGNC: 18608

    OMIM: 610986

    KEGG: hsa:79705

    STRING: 9606.ENSP00000373600

    UniGene: Hs.407918



主站蜘蛛池模板: 欧美国产综合欧美视频| 精品少妇人妻av免费久久洗澡| 国产熟妇按摩3p高潮大叫| …日韩人妻无码精品一专区| 亚洲高清乱码午夜电影网| 国产麻豆精品精东影业av网站| 欧美亚洲色欲色一欲www| 日韩人妻无码免费视频一区二区| 长腿校花无力呻吟娇喘的视频| 国产剧情av麻豆香蕉精品| 99国产精品久久久蜜芽| aaa欧美色吧激情视频| 少妇无码av无码专区| 动漫av纯肉无码av在线播放| 国产做无码视频在线观看浪潮| 两性色午夜视频免费老司机| 狠狠色丁香久久综合| 无码人妻久久久一区二区三区| 99re6热在线精品视频观看| 狠狠色噜噜狠狠狠狠蜜桃| 中文字幕人乱码中文| 久久99国产精品久久99果冻传媒| 亚洲www啪成人一区二区| 果冻传媒一区二区天美传媒| 好男人社区影院www| 久久人妻内射无码一区三区| 精品国产一区二区三区四区精华液 | 人妻少妇偷人精品无码| 亚洲制服 视频在线观看| 无码色av一二区在线播放| 色鬼7777久久| 仙踪林果冻传媒一区二区| 三级无码在钱av无码在钱| 中国熟妇人妻xxxxx| 久久精品噜噜噜成人| 精品婷婷色一区二区三区| 欧美精品18videosex性欧| 色天使久久综合网天天| 男女啪啪做爰高潮免费网站| 国语高潮无遮挡无码免费看| 人与动人物xxxx毛片|