在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LOXL3 Antibody

LOXL3 Antibody

  • 中文名稱：
    LOXL3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA013042LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA013042LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA013042LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LOXL3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LOXL3
  • 別名：
    LOXL antibody; Loxl3 antibody; LOXL3_HUMAN antibody; Lysyl oxidase homolog 3 antibody; Lysyl oxidase like 3 antibody; Lysyl oxidase-like protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Lysyl oxidase homolog 3 protein (401-608AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，LOXL3 Antibody (CSB-PA013042LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于LOXL3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA013042LB01HU LOXL3 Antibody, HRP conjugated ELISA
    FITC CSB-PA013042LC01HU LOXL3 Antibody, FITC conjugated
    Biotin CSB-PA013042LD01HU LOXL3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues on STAT3.; Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII.; Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV.
  • 基因功能參考文獻(xiàn)：
    1. Missense variant in LOXL3 gene is associated with nonsyndromic cleft palate. PMID: 29802726
    2. By deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, Loxl3 regulates Stat3 dimerization and transcriptional activity. CD4+ T cell differentiation in inflammatory responses is regulated by the Loxl3-Stat3 signaling pathway PMID: 28065600
    3. Our results suggest that null mutations in LOXL3 are likely associated with autosomal recessive early-onset high myopia. LOXL3 is a potential candidate gene for high myopia, but this possibility should be confirmed in additional studies. PMID: 26957899
    4. LOXL3 is a novel candidate gene for autosomal recessive Stickler syndrome. PMID: 25663169
    5. The human lysyl oxidase-like 3 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis. PMID: 21740577
    6. Lysyl-oxidase-like 3 interacts and cooperates with Snail to downregulate E-cadherin expression, and control epithelial-mesenchymal transitions and carcinoma progression. PMID: 16096638
    7. LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of which function as amine oxidases with distinct tissue and substrate specificities from one another. PMID: 17018530
    8. Breast carcinoma effusions showed significantly higher LOXL2 and lower LOXL3 expression compared to primary carcinomas. PMID: 19015874
    9. Expression of LOXL, LOXL2, LOXL3 and LOXL4 was not statistically associated with tumor location, stage, growth type, or differentiation status in colorectal adenocarcinomas PMID: 19724858

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by mutations affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899).
  • 亞細(xì)胞定位：
    Secreted, extracellular space. Cytoplasm. Nucleus.; [Isoform 1]: Secreted, extracellular space.; [Isoform 2]: Cytoplasm. Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 組織特異性：
    Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine. Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung. In eye, present in all layers of corneas as well as in the limbus and conju
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13869

    OMIM: 607163

    KEGG: hsa:84695

    STRING: 9606.ENSP00000264094

    UniGene: Hs.469045



主站蜘蛛池模板： 亚洲国产精品久久久久久久| 免费人成网站视频在线观看| 亚洲男人的天堂在线aⅴ视频| 最新国产麻豆aⅴ精品无码| 欧美人妻精品一区二区三区| 日本护士毛茸茸高潮| 日本久久高清一区二区三区毛片| 偷拍农村老熟妇xxxxx7视频| 亚洲中文字幕无码久久| 成人免费无码av| 亚洲国产成人va在线观看天堂| 伊人久久大香线蕉综合5g| 久久久久久人妻精品一区| 国产92成人精品视频免费 | 少妇高潮毛片免费看| 双腿张开被9个男人调教| 亚洲日本在线在线看片| 亚洲愉拍二区一区三区| 人妻 日韩 欧美 综合 制服| 一区二区无码免费视频网站| 国产sp调教打屁股视频网站| 手机国产乱子伦精品视频| 国产男女爽爽爽免费视频| 亚洲精品一区国产| 少妇乳大丰满在线播放| 国产九九九九九九九a片| 亚洲第一se情网站| 女人裸露免费视频无遮挡网站 | 精品夜夜爽欧美毛片视频| 狼人亚洲国内精品自在线| 色综合久久婷婷五月| 无码精品尤物一区二区三区| 国产xxxxx在线观看| 精品999日本久久久影院| 国产精品美女久久久网站| 天堂а√在线中文在线新版| 好紧好爽免费午夜视频| 三级全黄的视频在线观看| 国产欧美一区二区三区在线看| 男男gv白嫩小受gv在线播放| 欧美成人aa大片|