在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LOXL3 Antibody

LOXL3 Antibody

  • 中文名稱：
    LOXL3兔多克隆抗體
  • 貨號：
    CSB-PA038096
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA038096(LOXL3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LOXL3
  • 別名：
    LOXL antibody; Loxl3 antibody; LOXL3_HUMAN antibody; Lysyl oxidase homolog 3 antibody; Lysyl oxidase like 3 antibody; Lysyl oxidase-like protein 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human LOXL3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues on STAT3.; Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII.; Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV.
  • 基因功能參考文獻：
    1. Missense variant in LOXL3 gene is associated with nonsyndromic cleft palate. PMID: 29802726
    2. By deacetylating and deacetyliminating Stat3 on multiple acetyl-lysine sites in nuclei, Loxl3 regulates Stat3 dimerization and transcriptional activity. CD4+ T cell differentiation in inflammatory responses is regulated by the Loxl3-Stat3 signaling pathway PMID: 28065600
    3. Our results suggest that null mutations in LOXL3 are likely associated with autosomal recessive early-onset high myopia. LOXL3 is a potential candidate gene for high myopia, but this possibility should be confirmed in additional studies. PMID: 26957899
    4. LOXL3 is a novel candidate gene for autosomal recessive Stickler syndrome. PMID: 25663169
    5. The human lysyl oxidase-like 3 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis. PMID: 21740577
    6. Lysyl-oxidase-like 3 interacts and cooperates with Snail to downregulate E-cadherin expression, and control epithelial-mesenchymal transitions and carcinoma progression. PMID: 16096638
    7. LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of which function as amine oxidases with distinct tissue and substrate specificities from one another. PMID: 17018530
    8. Breast carcinoma effusions showed significantly higher LOXL2 and lower LOXL3 expression compared to primary carcinomas. PMID: 19015874
    9. Expression of LOXL, LOXL2, LOXL3 and LOXL4 was not statistically associated with tumor location, stage, growth type, or differentiation status in colorectal adenocarcinomas PMID: 19724858

    顯示更多

    收起更多

  • 相關疾病：
    Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by mutations affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899).
  • 亞細胞定位：
    Secreted, extracellular space. Cytoplasm. Nucleus.; [Isoform 1]: Secreted, extracellular space.; [Isoform 2]: Cytoplasm. Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 組織特異性：
    Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine. Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung. In eye, present in all layers of corneas as well as in the limbus and conju
  • 數據庫鏈接：

    HGNC: 13869

    OMIM: 607163

    KEGG: hsa:84695

    STRING: 9606.ENSP00000264094

    UniGene: Hs.469045



主站蜘蛛池模板： 欧洲美女黑人粗性暴交视频| 色狠狠av老熟女| 久久亚洲私人国产精品| 狠狠做深爱婷婷丁香综合| 精品一卡2卡三卡4卡乱码精品视频| 农村乱人伦一区二区| 亚洲 另类 熟女 字幕| 在线播放无码高潮的视频| 久久综合99re88久久爱| 国产 | 欧洲野花视频欧洲1| 亚洲欧美国产va在线播放| 人人人妻人人澡人人爽欧美一区| 成人精品视频一区二区三区| 亚洲综合精品第一页| 中文字幕亚洲码在线| 久在线观看福利视频| 中文字幕第一区高清av| 亚洲熟妇av一区二区三区浪潮| 国产在线精品一区二区三区| 国产麻豆md传媒视频| 麻豆精产一二三产区| 777米奇色狠狠俺去啦| 亚洲春色在线视频| 国产又爽又黄无码无遮挡在线观看| 最新亚洲伦理中文字幕| 丰满少妇人妻无码| 中国女人内谢69xxxxxa片| 国产熟妇疯狂4p交在线播放| 亚洲精品久久久久国产剧8| 丰满人妻av无码一区二区三区| 熟女俱乐部五十路六十路av| 亚洲一卡2卡三卡4卡国色天香| 久久精品国产一区二区电影| 理论片87福利理论电影| 玩弄了裸睡少妇人妻野战| 少妇人妻无码专区在线视频| 熟女人妻aⅴ一区二区三区60路| 国产精品久久久久久久妇| 无人区一线二线三线乱码| 国产精品久久久福利| 国产做无码视频在线观看浪潮|