在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LNX1 Antibody

  • 中文名稱:
    LNX1兔多克隆抗體
  • 貨號:
    CSB-PA013022GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LNX1
  • 別名:
    LNX1 antibody; LNX antibody; PDZRN2 antibody; UNQ574/PRO1136 antibody; E3 ubiquitin-protein ligase LNX antibody; EC 2.3.2.27 antibody; Ligand of Numb-protein X 1 antibody; Numb-binding protein 1 antibody; PDZ domain-containing RING finger protein 2 antibody; RING-type E3 ubiquitin transferase LNX antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human LNX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
  • 基因功能參考文獻:
    1. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells PMID: 29190716
    2. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling. PMID: 16324299
    3. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis. PMID: 22889411
    4. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold. PMID: 22087225
    5. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. PMID: 22066909
    6. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis PMID: 22045731
    7. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway. PMID: 21104141
    8. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1. PMID: 19701800
    9. identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway PMID: 15367597
    10. The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis. PMID: 16002321
    11. The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. PMID: 17936276
    12. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473
    13. A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells. PMID: 16122940
    14. The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins. PMID: 9535908
    15. Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene. PMID: 17504929

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 組織特異性:
    Expressed in heart, placenta, kidney, pancreas and brain.
  • 數據庫鏈接:

    HGNC: 6657

    OMIM: 609732

    KEGG: hsa:84708

    STRING: 9606.ENSP00000263925

    UniGene: Hs.518760



主站蜘蛛池模板: av天堂午夜精品一区| 噜噜色综合天天综合网mp3| 成人网站色52色在线观看| 日本高清不卡aⅴ免费网站| 少妇高潮太爽了在线视频| 在线观看免费人成视频| 国模无码大尺度一区二区三区| 久久综合九色欧美综合狠狠| 欧美zozo另类特级| 国产精自产拍在线看中文| 日韩人妻不卡一区二区三区 | 破了亲妺妺的处免费视频国产| 日韩av无码精品人妻系列| 免费观看的av在线播放| 成人欧美一区二区三区a片| 男女猛烈无遮挡免费视频app| 亚洲中文字幕无码永久在线不卡| 亚洲天堂男人影院| 免费毛片a线观看| 久久视频这里只有精品在线观看| 亚洲精品无码ma在线观看| √天堂中文官网8在线| 四虎影成人精品a片| 久久人人爽人人爽人人片av| 免费看无码自慰一区二区| 成人无遮挡裸免费视频在线观看| 精品国产三级a∨在线欧美| 无码人妻丰满熟妇啪啪网站| 国产国拍精品av在线观看| 又爆又大又粗又硬又黄的a片 | 国产精品永久在线观看| 日本理伦片午夜理伦片| 2021国产精品国产精华| 热re99久久精品国产99热| 18禁裸体女免费观看| 一本之道av不卡精品| 亚洲成av人片在线观看一区二区三区| а天堂中文最新一区二区三区| 亚洲精品久久久www| 日本一区二区三区免费播放视频站| 亚洲欧美日韩综合av|