在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LNX1 Antibody, FITC conjugated

LNX1 Antibody, FITC conjugated

  • 中文名稱：
    LNX1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA848393LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LNX1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LNX1
  • 別名：
    LNX1 antibody; LNX antibody; PDZRN2 antibody; UNQ574/PRO1136 antibody; E3 ubiquitin-protein ligase LNX antibody; EC 2.3.2.27 antibody; Ligand of Numb-protein X 1 antibody; Numb-binding protein 1 antibody; PDZ domain-containing RING finger protein 2 antibody; RING-type E3 ubiquitin transferase LNX antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase LNX protein (133-259AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
  • 基因功能參考文獻：
    1. study provided the evidences that LNX1 signaling plays important roles in regulating the stemness of colon cancer cells PMID: 29190716
    2. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling. PMID: 16324299
    3. LNX1-mediated ubiquitination and degradation of PBK inhibited cell proliferation and enhanced sensitivity to doxorubicin-induced apoptosis. PMID: 22889411
    4. identify and confirm six novel LNX1 binding partners: KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2 and PBK, and suggest that LNX1 functions as a signalling scaffold. PMID: 22087225
    5. The authors found a high level of LNX1 and LNX2 mRNAs in endocarditis, the principal manifestation of chronic Q fever, but not in acute Q fever. PMID: 22066909
    6. LNX1 and LNX2 interact with CD8alpha and promote its ubiquitylation and endocytosis PMID: 22045731
    7. Down-regulation of LNX could result in cell cycle arrest in G0/G1 phase through inhibition of beta-catenin, MAPK, NFkappaB, c-Myc-dependent pathway and activation of p53, TGF-beta-dependent pathway. PMID: 21104141
    8. LNX and RhoC might be part of a larger protein complex that would have important functions in signaling transduction about regulating the transcriptional activities of AP-1. PMID: 19701800
    9. identifed ligand of Numb protein X as an Np9-interacting partner; findings point to the possibility that Np9 affects tumorigenesis through the LNX/Numb/Notch pathway PMID: 15367597
    10. The presence of multiple protein binding domains involved in signal transduction and interaction with Numb and SKIP suggested an important role for LNX in tumorogenesis. PMID: 16002321
    11. The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. PMID: 17936276
    12. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473
    13. A direct interaction between ErbB2 and mouse LNX1 was identified, suggesting that LNX1 may be involved in neuregulin-1/ErbB signaling in perisynaptic Schwann cells. PMID: 16122940
    14. The tyrosine phosphorylation of the LDNPAY sequence motif in mouse LNX could generate a binding site for the phosphorylation-dependent binding of other PTB domain-containing proteins. PMID: 9535908
    15. Describes various glioblastoma multiforms containing the amplicon on chromosomal segment 4q12, including the LNX1 gene. PMID: 17504929

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in heart, placenta, kidney, pancreas and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6657

    OMIM: 609732

    KEGG: hsa:84708

    STRING: 9606.ENSP00000263925

    UniGene: Hs.518760



主站蜘蛛池模板： 男人一边吃奶一边做爰免费视频| 中国老妇xxxx性开放| 国产女人高潮毛片| 在线播放无码高潮的视频| 97无码免费人妻超级碰碰夜夜| 日韩精品一区二区av在线| 久久精品国产久精久精| 成人爽a毛片免费啪啪| 国内少妇偷人精品免费| 男女无遮挡猛进猛出免费观看视频| 97av麻豆蜜桃一区二区| 东京热无码av一区二区| 中文字幕热久久久久久久| 两性色午夜视频免费老司机| 久草热久草热线频97精品| 国产精品.xx视频.xxtv| 亚洲va久久久噜噜噜久久天堂| 色综合亚洲一区二区小说| 国产初高中生真实在线视频| 精品无码国产av一区二区| 亚洲国产制服丝袜无码av| 日本久久综合久久鬼色| 老熟女重囗味hdxx70星空| 欧美叉叉叉bbb网站| 夜夜欢性恔免费视频| 欧美阿v高清资源在线| 美女脱了内裤张开腿让男人桶网站| 欧美成人免费全部| 娜娜麻豆国产电影| 午夜男女xx00视频福利| 欧美日韩国产精品自在自线| 国产粗话肉麻对白在线播放| 久视频精品线在线观看| 自拍性旺盛老熟女| 国产有奶水哺乳期无码avav| 18禁黄网站禁片免费观看不卡| av性色在线乱叫| 国产午夜精品av一区二区| 很色很爽很黄裸乳视频| 国产精品久久久久久无码五月| 加勒比东京热无码一区|