LLGL2 Antibody
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中文名稱：LLGL2兔多克隆抗體
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貨號：CSB-PA032798
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA032798(LLGL2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：HGL antibody; Human giant larvae homolog antibody; L2GL2 antibody; L2GL2_HUMAN antibody; Lethal 2 giant larvae protein homolog 2 antibody; Lethal giant larvae homolog 2 antibody; Lethal(2) giant larvae protein homolog 2 antibody; LGL2 antibody; LLGL2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthetic peptide of Human LLGL2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
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基因功能參考文獻：
- The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
- It is correlated with lymphatic invasion and lymph node metastasis. PMID: 24318287
- Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia PMID: 23332925
- Hugl-2 induces MET and suppresses Snail tumorigenesis. PMID: 22580609
- Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. PMID: 23110097
- There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. PMID: 20941506
- Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. PMID: 20233622
- binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division PMID: 15632202
- The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. PMID: 18155665
- Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. PMID: 18199550
- We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. PMID: 19407852
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亞細(xì)胞定位：Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
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蛋白家族：WD repeat L(2)GL family
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數(shù)據(jù)庫鏈接：
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