在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LILRA2 Antibody

  • 中文名稱:
    LILRA2兔多克隆抗體
  • 貨號:
    CSB-PA012934GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    LILRA2 antibody; ILT1 antibody; LIR7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 2 antibody; CD85 antigen-like family member H antibody; Immunoglobulin-like transcript 1 antibody; ILT-1 antibody; Leukocyte immunoglobulin-like receptor 7 antibody; LIR-7 antibody; CD antigen CD85h antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human LILRA2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens.
  • 基因功能參考文獻:
    1. findings demonstrate that LILRA2 is a type of innate immune receptor in the host immune system that detects immunoglobulin abnormalities caused by microbial pathogens. PMID: 27572839
    2. LILRA2 recognizes microbially cleaved antibodies and activates innate immunity, suggesting that LILRA2 detects dangerous immunological situations in which antibodies are destroyed by pathogens. PMID: 27572839
    3. LILRA2-mediated activation of monocytes is significantly different to LPS and that LILRA2 selectively modulates LPS-mediated monocyte activation and FcgammaRI-dependent phagocytosis. PMID: 22479404
    4. LIR7 is an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport PMID: 12529506
    5. Cross-linking of basophil LIR7 resulted in the concentration-dependent net release of histamine and cysteinyl leukotrienes that were maximal at 30 minutes, and of IL-4 that was maximal at 4 hours PMID: 15242876
    6. Progenitor mast cells expressed cell surface activating LILRA2. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface. PMID: 17998301
    7. LILRA2 activation, by altering GM-CSF-induced monocyte differentiation into immature DC, provides a mechanism for down-regulating the ability of the innate immune system to activate the adaptive T cell response while promoting an inflammatory response. PMID: 18056355
    8. LILRA2 Delta 419-421 isoform encoded by the splice site SNP may play a role in systemic lupus erythematosus and microscopic polyangiitis. PMID: 18273033
    9. The authors report the LILRA2 extracellular D1D2 domain crystal structure, which reveals structural shifts of the corresponding MHC-binding amino acid residues in comparison with LILR B1/B2, explaining its non-binding to MHC molecules. PMID: 19230061

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.
  • 組織特異性:
    Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells.
  • 數據庫鏈接:

    HGNC: 6603

    OMIM: 604812

    KEGG: hsa:11027

    STRING: 9606.ENSP00000251377

    UniGene: Hs.655593



主站蜘蛛池模板: 日韩不卡1卡2卡三卡网站| 国内精品美女视频免费直播| 满春阁精品a∨在线观看| 亚洲欧美中文高清在线专区| 亚洲蜜桃v妇女| 久久精品国产大片免费观看| 日韩在线永久免费播放 | 正在播放酒店约少妇高潮| 国产无吗一区二区三区在线欢| 亚洲字幕av一区二区三区四区| 无码av片av片av无码| 东北老女人高潮大喊舒服死了| 怡红院av亚洲一区二区三区h| 97在线视频人妻无码| 久久综合伊人九色综合| 伊人大杳焦在线| 长腿校花无力呻吟娇喘的视频| 99re热视频这里只精品| 免费无码av片在线观看潮喷 | 午夜福利理论片高清在线| 少妇呻吟白浆高潮啪啪69| 国产精品毛片大码女人| 久久综合九色欧美综合狠狠| 人妻夜夜爽天天爽一区| 在线看免费无码av天堂的| 欧美肉大捧一进一出免费视频 | 亚洲粉嫩高潮的18p| 中文字幕久久久久人妻| 免费观看亚洲人成网站| 亚洲国产精彩中文乱码av| 99精品日本二区留学生| 无码视频一区二区三区| 国模无码一区二区三区| 国产午夜无码片免费| 免费午夜福利不卡片在线播放| 国产色xx群视频射精| 国产乱子伦三级在线播放| 中文字幕无码中文字幕有码a| 小荡货好紧好爽奶头大视频| 国产aⅴ激情无码久久久无码| 久久久亚洲欧洲日产国码二区|