在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LILRA2 Antibody

  • 中文名稱:
    LILRA2兔多克隆抗體
  • 貨號:
    CSB-PA940104
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, using LILRA2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LILRA2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human LILRA2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1. Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils. In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4. In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4. Does not bind class I MHC antigens.
  • 基因功能參考文獻:
    1. findings demonstrate that LILRA2 is a type of innate immune receptor in the host immune system that detects immunoglobulin abnormalities caused by microbial pathogens. PMID: 27572839
    2. LILRA2 recognizes microbially cleaved antibodies and activates innate immunity, suggesting that LILRA2 detects dangerous immunological situations in which antibodies are destroyed by pathogens. PMID: 27572839
    3. LILRA2-mediated activation of monocytes is significantly different to LPS and that LILRA2 selectively modulates LPS-mediated monocyte activation and FcgammaRI-dependent phagocytosis. PMID: 22479404
    4. LIR7 is an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport PMID: 12529506
    5. Cross-linking of basophil LIR7 resulted in the concentration-dependent net release of histamine and cysteinyl leukotrienes that were maximal at 30 minutes, and of IL-4 that was maximal at 4 hours PMID: 15242876
    6. Progenitor mast cells expressed cell surface activating LILRA2. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface. PMID: 17998301
    7. LILRA2 activation, by altering GM-CSF-induced monocyte differentiation into immature DC, provides a mechanism for down-regulating the ability of the innate immune system to activate the adaptive T cell response while promoting an inflammatory response. PMID: 18056355
    8. LILRA2 Delta 419-421 isoform encoded by the splice site SNP may play a role in systemic lupus erythematosus and microscopic polyangiitis. PMID: 18273033
    9. The authors report the LILRA2 extracellular D1D2 domain crystal structure, which reveals structural shifts of the corresponding MHC-binding amino acid residues in comparison with LILR B1/B2, explaining its non-binding to MHC molecules. PMID: 19230061

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.
  • 組織特異性:
    Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells.
  • 數據庫鏈接:

    HGNC: 6603

    OMIM: 604812

    KEGG: hsa:11027

    STRING: 9606.ENSP00000251377

    UniGene: Hs.655593



主站蜘蛛池模板: 欧美人与性动交α欧美精品| 亚洲国产精品久久久久4婷婷| 国产精品卡一卡2卡三卡网站| 国产亚洲美女精品久久久2020 | 精品黑人一区二区三区久久| 在线看片免费人成视频福利 | 华人少妇被黑人粗大的猛烈进| 午夜成人理论福利片| 亚洲熟妇无码av另类vr影视| 99久久精品国产一区二区| 欧美性猛交久久久乱大交小说| 国产v亚洲v天堂a无码| 国产毛片精品av一区二区| 国产亚洲精品福利视频| 国产一区二区三区精品视频 | 天天做天天爱夜夜爽毛片毛片| 亚洲国产婷婷六月丁香| 中无码人妻丰满熟妇啪啪| 日韩免费无砖专区2020狼| 丰满少妇熟乱xxxxx视频| 99精品久久久久久久婷婷| 人妻出轨av中文字幕| 伊人久久大香线蕉无码不卡| 亚洲爆乳无码专区| 国产乱子伦农村叉叉叉| 国精品人妻无码一区二区三区性色| 亚洲精品久久婷婷丁香51| 又大又粗欧美黑人aaaaa片| 亚洲中文字幕永久在线不卡| 午夜免费啪视频观看视频| 亚洲欧美日韩久久精品第一区| 色综合久久88色综合天天| 免费无码又爽又刺激软件下载| 国产全肉乱妇杂乱视频| 99久久无码私人网站| 熟女毛多熟妇人妻在线视频| 色综合无码av网站| 强奷乱码中文字幕熟女一| 国内精品视这里只有精品| 99爱在线精品视频免费观看| 男女后进式猛烈xx00动态图片|