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  4. LFNG Antibody

LFNG Antibody

  • 中文名稱：
    LFNG兔多克隆抗體
  • 貨號(hào)：
    CSB-PA839868ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: LFNGantibody at 4.43μg/ml
      Lane 1: Mouse spleen tissue
      Lane 2: K562 whole cell lysate
      Lane 3: HL60 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42, 29, 40, 36 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA839868ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA839868ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LFNG Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    3-N-acetylglucosaminyltransferase lunatic fringe antibody; Beta-1 antibody; Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody; lfng antibody; LFNG_HUMAN antibody; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody; SCDO3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.
  • 基因功能參考文獻(xiàn)：
    1. Genetic interaction between lunatic fringe and TP53 was identified in breast cancer tumorigenesis. PMID: 28938159
    2. TGFBR2 signaling can affect Notch1 glycosylation via regulation of glycosyltransferase LFNG expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells. PMID: 27156840
    3. LFNG expression correlates with expansion of cancer stem cell populations and NKX3.1 expression in human prostate cancer. PMID: 24709423
    4. Reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer. PMID: 22624713
    5. Mutation of the LFNG gene causes spondylocostal dysostosis with a severe vertebral phenotype, reinforcing the hypothesis that proper regulation of the Notch signaling pathway is an absolute requirement for the correct patterning of the axial skeleton. PMID: 16385447

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  • 相關(guān)疾病：
    Spondylocostal dysostosis 3, autosomal recessive (SCDO3)
  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 31 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6560

    OMIM: 602576

    KEGG: hsa:3955

    STRING: 9606.ENSP00000222725

    UniGene: Hs.159142



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