在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LFNG Antibody

LFNG Antibody

  • 中文名稱：
    LFNG兔多克隆抗體
  • 貨號：
    CSB-PA570737
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from MCF-7 cells and HUVEC cells, using LFNG antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LFNG Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human LFNG.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.
  • 基因功能參考文獻：
    1. Genetic interaction between lunatic fringe and TP53 was identified in breast cancer tumorigenesis. PMID: 28938159
    2. TGFBR2 signaling can affect Notch1 glycosylation via regulation of glycosyltransferase LFNG expression and provide a first mechanistic example for altered glycosylation in microsatellite instability colorectal tumor cells. PMID: 27156840
    3. LFNG expression correlates with expansion of cancer stem cell populations and NKX3.1 expression in human prostate cancer. PMID: 24709423
    4. Reduced LFNG expression facilitates JAG/NOTCH luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer. PMID: 22624713
    5. Mutation of the LFNG gene causes spondylocostal dysostosis with a severe vertebral phenotype, reinforcing the hypothesis that proper regulation of the Notch signaling pathway is an absolute requirement for the correct patterning of the axial skeleton. PMID: 16385447

    顯示更多

    收起更多

  • 相關疾病：
    Spondylocostal dysostosis 3, autosomal recessive (SCDO3)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 31 family
  • 數據庫鏈接：

    HGNC: 6560

    OMIM: 602576

    KEGG: hsa:3955

    STRING: 9606.ENSP00000222725

    UniGene: Hs.159142



主站蜘蛛池模板： 国产人与禽zoz0性伦多活几年| 国产制服日韩丝袜86页| 亚洲欧洲中文日韩乱码av| 亚洲精品成a人在线观看| 人妻夜夜爽天天爽三区| 秋霞鲁丝片av无码| 久久久一本精品久久精品六六| 黑人巨大精品欧美一区二区免费| 欧美激情综合五月色丁香| 少妇内射兰兰久久| 亚洲国产精品第一区二区三区| 成人午夜亚洲精品无码区| 揄拍成人国产精品视频| 开心五月综合亚洲| 乌克兰性欧美精品高清| 欧美性大战久久久久xxx| 国产综合久久久久| 亚洲国产午夜精华无码福利 | 久久久综合九色综合88| 让少妇高潮无乱码高清在线观看 | 日日噜噜噜噜夜夜爽亚洲精品 | 日韩国产成人无码av毛片蜜柚| 亚洲高清毛片一区二区| 男女性杂交内射女bbwxz| 国产成人影院一区二区三区| 色欲综合久久中文字幕网| 色噜噜狠狠狠综合曰曰曰| 久久国产欧美日韩精品图片| 国产乱人伦偷精品视频免| 精品一区二区三区在线观看| 狠狠躁夜夜躁人人爽天天不卡| 午夜免费国产体验区免费的| 在线天堂免费观看.www| 欧美人与性动交ccoo| 国产免费一区二区三区免费视频 | 成人无码精品免费视频在线观看| 无套中出丰满人妻无码| 色综合色综合久久综合频道88| 久久毛片免费看一区二区三区| 又大又硬又黄的免费视频| 精品国产乱码久久久人妻|