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  4. KY Antibody

KY Antibody

  • 中文名稱：
    KY兔多克隆抗體
  • 貨號：
    CSB-PA012702LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate
      All lanes: KY antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64, 42, 73, 76 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA012702LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cells with CSB-PA012702LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KY Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KY
  • 別名：
    KY antibody; KY_HUMAN antibody; Kyphoscoliosis peptidase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kyphoscoliosis peptidase protein (23-170AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KY Antibody (CSB-PA012702LA01HU)，的標記方式是Non-conjugated。對于KY Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA012702LB01HU KY Antibody, HRP conjugated ELISA
    FITC CSB-PA012702LC01HU KY Antibody, FITC conjugated
    Biotin CSB-PA012702LD01HU KY Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.
  • 基因功能參考文獻：
    1. This study shown Kyphoscoliosis peptidase (KY) mutation causes a novel congenital myopathy with core targetoid defects in two bother. PMID: 27484770
    2. Homozygous KY mutation was identified as a cause of progressive hereditary spastic paraplegia. High KY transcript levels were demonstrated in muscular organs and lower expression in the CNS. PMID: 28488683
    3. Homozygous c.1071delG, p.(Thr358Leufs*3) variant of KY causes neuromuscular disorder by introducing a premature stop codon. PMID: 27485408
    4. KY expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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  • 相關疾病：
    Myopathy, myofibrillar, 7 (MFM7)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Transglutaminase-like superfamily
  • 組織特異性：
    Highly expressed in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 26576

    OMIM: 605739

    KEGG: hsa:339855

    STRING: 9606.ENSP00000397598

    UniGene: Hs.146730



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