在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT16 Antibody

  • 中文名稱:
    KRT16兔多克隆抗體
  • 貨號:
    CSB-PA012515GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CK 16 antibody; CK-16 antibody; CK16 antibody; Cytokeratin 16 antibody; Cytokeratin-16 antibody; Cytokeratin16 antibody; FNEPPK antibody; Focal non epidermolytic palmoplantar keratoderma antibody; K 16 antibody; K16 antibody; K1C16_HUMAN antibody; K1CP antibody; Keratin 1 type I antibody; Keratin 16 antibody; Keratin antibody; Keratin type I cytoskeletal 16 antibody; Keratin-16 antibody; Keratin16 antibody; KRT 16 antibody; Krt16 antibody; KRT16A antibody; NEPPK antibody; PC1 antibody; type I cytoskeletal 16 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human KRT16
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
  • 基因功能參考文獻:
    1. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
    2. results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
    3. inflammatory cytokines promoted Nrf2 nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16, and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis. PMID: 28576737
    4. The wider spectrum of KRT16 mutations suggests that changes in codons 125, 127, and 132 are most commonly responsible for PC-1 and that proline substitution mutations at codons 127 or 128 may produce more severe disease PMID: 24357266
    5. analysis of a new p.Leu421Pro (c.1262T>C) mutation in the highly conserved helix termination motif of K16 in a large Spanish family that may have a role in pachyonychia congenita PMID: 24118415
    6. Keratin 16 regulates innate immunity in response to epidermal barrier breach. PMID: 24218583
    7. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
    8. Patients with p.Asn125Asp and p.Arg127Pro mutations in KRT16 exhibited more severe disease than patients carrying p.Asn125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail involvement, and impact on daily quality of life. PMID: 21160496
    9. Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder. PMID: 20722389
    10. coinheritance of mutations in KRT16 and filaggrin may aggravate the pachyonychia congenita phenotype PMID: 19785597
    11. disease-associated keratin 16 expression is induced by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun PMID: 12954631
    12. K16 expression is observed in non-lesional psoriatic skin and may serve as a marker of preclinical psoriasis. PMID: 15239676
    13. ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression. PMID: 17623675
    14. DPPIV-expression and enzyme activity, Ki-67 antigen and K16 are significantly upregulated in the centre and inner margin of the psoriatic lesion compared to clinically uninvolved skin and the healthy volunteers skin. PMID: 18496701
    15. Antikeratin 16 autoAbs are involved in psoriasis, by exaggerating the innate immune response of keratinocytes. PMID: 18557933
    16. Infection by HPV stimulates the expression of K16 PMID: 19515043

    顯示更多

    收起更多

  • 相關疾病:
    Pachyonychia congenita 1 (PC1); Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1)
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the corneal epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 6423

    OMIM: 148067

    KEGG: hsa:3868

    STRING: 9606.ENSP00000301653

    UniGene: Hs.655160



主站蜘蛛池模板: 中文字幕亚洲综合久久菠萝蜜| 国产v亚洲v天堂无码久久久 | 伊人久久大香线蕉av网站| 成年免费视频播放网站推荐| 久久人妻国产精品31| 欧美肥老太交性506070| 国产精品久久久久久久久久久久午夜片| 自慰小少妇毛又多又黑流白浆| 国产在线观看黄av免费| 日韩欧美亚洲中文乱码| 国产亚洲久久久久久久| 亚洲国产av一区二区三区四区| 四虎永久在线精品免费一区二区| 手机真实国产乱子伦对白视频| 欧洲熟妇精品视频| 精品国产不卡一区二区三区| 香港日本三级亚洲三级| 日韩人妻无码免费视频一二区| 色窝窝免费播放视频在线| 亚洲国产精品久久久久久久| 久久久精品波多野结衣| 中文字幕人妻伦伦| 亚洲日韩小电影在线观看| 亚洲国产丝袜精品一区| 性色av无码一区二区三区人妻| 亚洲午夜精品a片久久www慈禧| 男人天堂2018亚洲男人天堂| 99久久国产综合精品五月天喷水| 男人的天堂在线视频| 荫蒂添的好舒服视频囗交| 国产午夜无码片免费| 无码av高潮喷水无码专区线| 精品无码专区毛片| 国色天香成人网| av无码av无码专区| av无码久久久久不卡网站蜜桃| 中文字幕人妻中文av不卡专区 | 国产欧美日韩国产高清| 天堂在/线资源中文在线8| 2020国产在线拍揄自揄视频| 国产福利一区二区三区在线观看|