在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KRT16 Antibody

KRT16 Antibody

  • 中文名稱：
    KRT16兔多克隆抗體
  • 貨號：
    CSB-PA012515LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: KRT16 antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52 kDa
    • IHC image of CSB-PA012515LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA012515LA01HU diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA012515LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KRT16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CK 16 antibody; CK-16 antibody; CK16 antibody; Cytokeratin 16 antibody; Cytokeratin-16 antibody; Cytokeratin16 antibody; FNEPPK antibody; Focal non epidermolytic palmoplantar keratoderma antibody; K 16 antibody; K16 antibody; K1C16_HUMAN antibody; K1CP antibody; Keratin 1 type I antibody; Keratin 16 antibody; Keratin antibody; Keratin type I cytoskeletal 16 antibody; Keratin-16 antibody; Keratin16 antibody; KRT 16 antibody; Krt16 antibody; KRT16A antibody; NEPPK antibody; PC1 antibody; type I cytoskeletal 16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Keratin, type I cytoskeletal 16 protein (265-333AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KRT16 Antibody (CSB-PA012515LA01HU)，的標記方式是Non-conjugated。對于KRT16 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA012515LB01HU KRT16 Antibody, HRP conjugated ELISA
    FITC CSB-PA012515LC01HU KRT16 Antibody, FITC conjugated
    Biotin CSB-PA012515LD01HU KRT16 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
  • 基因功能參考文獻：
    1. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
    2. results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
    3. inflammatory cytokines promoted Nrf2 nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16, and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis. PMID: 28576737
    4. The wider spectrum of KRT16 mutations suggests that changes in codons 125, 127, and 132 are most commonly responsible for PC-1 and that proline substitution mutations at codons 127 or 128 may produce more severe disease PMID: 24357266
    5. analysis of a new p.Leu421Pro (c.1262T>C) mutation in the highly conserved helix termination motif of K16 in a large Spanish family that may have a role in pachyonychia congenita PMID: 24118415
    6. Keratin 16 regulates innate immunity in response to epidermal barrier breach. PMID: 24218583
    7. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
    8. Patients with p.Asn125Asp and p.Arg127Pro mutations in KRT16 exhibited more severe disease than patients carrying p.Asn125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail involvement, and impact on daily quality of life. PMID: 21160496
    9. Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder. PMID: 20722389
    10. coinheritance of mutations in KRT16 and filaggrin may aggravate the pachyonychia congenita phenotype PMID: 19785597
    11. disease-associated keratin 16 expression is induced by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun PMID: 12954631
    12. K16 expression is observed in non-lesional psoriatic skin and may serve as a marker of preclinical psoriasis. PMID: 15239676
    13. ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression. PMID: 17623675
    14. DPPIV-expression and enzyme activity, Ki-67 antigen and K16 are significantly upregulated in the centre and inner margin of the psoriatic lesion compared to clinically uninvolved skin and the healthy volunteers skin. PMID: 18496701
    15. Antikeratin 16 autoAbs are involved in psoriasis, by exaggerating the innate immune response of keratinocytes. PMID: 18557933
    16. Infection by HPV stimulates the expression of K16 PMID: 19515043

    顯示更多

    收起更多

  • 相關疾病：
    Pachyonychia congenita 1 (PC1); Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1)
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in the corneal epithelium (at protein level).
  • 數據庫鏈接：

    HGNC: 6423

    OMIM: 148067

    KEGG: hsa:3868

    STRING: 9606.ENSP00000301653

    UniGene: Hs.655160



主站蜘蛛池模板： 亚洲精品伊人久久久大香| 无码国产偷倩在线播放| 亚洲一码二码三码精华液| 国产亚洲精品久久久999蜜臀| 精品国产一区二区三区无码| 国产乱妇乱子视频在播放| 国产精品人成视频国模| 99热国产这里只有精品6| 亚洲免费观看视频| 国产国语老龄妇女a片| 中文乱码免费一区二区 | 欧美激情一区二区三区| 青青青国产在线观看免费| 伊人久久大香线蕉av五月天| 一本大道伊人av久久乱码| 久久久久99人妻一区二区三区| 亚洲欧美日本韩国| 天天做天天欢摸夜夜摸狠狠摸| 国产成人精品日本亚洲成熟| 精品人伦一区二区三电影| 国产精品久久久久电影网| 一本色道久久99一综合| 亚洲日韩中文无码久久| 久久精品av麻豆| 中文字幕久久精品无码| 久久久久成人网站| 亚洲午夜精品一区二区| 日韩一区二区三区射精| 亚洲hdmi高清线| 中文字幕日韩一区二区三区不卡| 国产麻豆精品av在线观看| 午夜视频在线观看免费完整版| 国产亚洲美女精品久久久2020| 精品国精品国产自在久国产87| 超碰国产天天做天天爽| 超清无码波多野吉衣中文| 伦埋琪琪电影院久久| 永久免费看啪啪的网站| 黄床片30分钟免费视频教程| 国产成人无码一区二区在线观看| 羞羞视频在线观看|