在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT12 Antibody, HRP conjugated

  • 中文名稱:
    KRT12兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA859510LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KRT12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CK-12 antibody; Cytokeratin-12 antibody; K12 antibody; K1C12_HUMAN antibody; Keratin 12 antibody; Keratin antibody; Keratin; type I cytoskeletal 12 antibody; Keratin-12 antibody; KRT12 antibody; type I cytoskeletal 12 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Keratin, type I cytoskeletal 12 protein (1-178AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in corneal epithelium organization, integrity and corneal keratin expression.
  • 基因功能參考文獻:
    1. KC can co-exist with GCD. The missense mutation (c.370G > A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD. PMID: 28567551
    2. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals. PMID: 24801514
    3. We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea. PMID: 24099278
    4. The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein. PMID: 23222558
    5. The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 in the concentration ranges tested. PMID: 23233254
    6. Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family. PMID: 20577595
    7. Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy. PMID: 12543196
    8. A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families. PMID: 16227835
    9. Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy PMID: 16352477
    10. Mutation associated with symptomatic phenotype of Meesmann's corneal dystrophy. Results in substitution of proline for arginine in helix termination motif that may disrupt normal helix, leading to dramatic structural change of keratin 12 protein. PMID: 17653038
    11. This is the second family recently diagnosed with Meesmann dystrophy in Denmark. The family represents its own distinct genotype, independent of previously reported ones. All patients with microcysts were asymptomatic. PMID: 18245975
    12. The novel L433R mutation of the KRT12 gene found in two members of this Japanese family caused Meesmann corneal dystrophy (MECD). PMID: 18661274

    顯示更多

    收起更多

  • 相關疾病:
    Corneal dystrophy, Meesmann (MECD)
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the corneal epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 6414

    OMIM: 122100

    KEGG: hsa:3859

    STRING: 9606.ENSP00000251643

    UniGene: Hs.66739



主站蜘蛛池模板: 亚洲中文字幕av不卡无码| 欧洲女人性开放免费网站| 日本一区二区三区不卡免费| 成人av片在线观看免费| 亚洲伊人久久精品影院| 日韩v亚洲v欧美v精品综合| 亚洲v欧美v国产v在线观看| 国产成人精品无码专区| 亚洲综合国产一区二区三区| 午夜伦yy44880影院| 3d成人h动漫网站入口| 好爽好舒服要高潮了视频| 久久久精品免费| 色综合欧美在线视频区| 亚洲日韩欧洲无码av夜夜摸| 婷婷四虎东京热无码群交双飞视频| 国产亚洲精品久久77777| 久久午夜神器| 18禁白丝喷水视频www视频| √最新版天堂资源在线| 国产99视频精品免费视频36| 中国少妇videos呻吟| 18无码粉嫩小泬无套在线观看| 狂野欧美性猛交xxxx| 红杏亚洲影院一区二区三区| 久久激情日本亚洲欧洲国产中文| 中文字幕亂倫免賛視頻| 国产乱码二卡3卡四卡| 午夜dv内射一区二区| 里番本子纯肉侵犯肉全彩无码| 国产精品v欧美精品∨日韩| 久久久久国产精品| 青青草国产线观看| 无码人妻久久一区二区三区app| 48沈阳熟女高潮嗷嗷叫| 日韩人妻无码一区二区三区| 樱花草在线社区www| 亚洲中文字幕精品久久| 香蕉蕉亚亚洲aav综合| 国产美女精品视频线播放| 毛片免费视频在线观看|