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  4. KRT12 Antibody, Biotin conjugated

KRT12 Antibody, Biotin conjugated

  • 中文名稱：
    KRT12兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA859510LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KRT12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CK-12 antibody; Cytokeratin-12 antibody; K12 antibody; K1C12_HUMAN antibody; Keratin 12 antibody; Keratin antibody; Keratin; type I cytoskeletal 12 antibody; Keratin-12 antibody; KRT12 antibody; type I cytoskeletal 12 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Keratin, type I cytoskeletal 12 protein (1-178AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in corneal epithelium organization, integrity and corneal keratin expression.
  • 基因功能參考文獻(xiàn)：
    1. KC can co-exist with GCD. The missense mutation (c.370G > A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD. PMID: 28567551
    2. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals. PMID: 24801514
    3. We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea. PMID: 24099278
    4. The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein. PMID: 23222558
    5. The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 in the concentration ranges tested. PMID: 23233254
    6. Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family. PMID: 20577595
    7. Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy. PMID: 12543196
    8. A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families. PMID: 16227835
    9. Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy PMID: 16352477
    10. Mutation associated with symptomatic phenotype of Meesmann's corneal dystrophy. Results in substitution of proline for arginine in helix termination motif that may disrupt normal helix, leading to dramatic structural change of keratin 12 protein. PMID: 17653038
    11. This is the second family recently diagnosed with Meesmann dystrophy in Denmark. The family represents its own distinct genotype, independent of previously reported ones. All patients with microcysts were asymptomatic. PMID: 18245975
    12. The novel L433R mutation of the KRT12 gene found in two members of this Japanese family caused Meesmann corneal dystrophy (MECD). PMID: 18661274

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  • 相關(guān)疾病：
    Corneal dystrophy, Meesmann (MECD)
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in the corneal epithelium (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6414

    OMIM: 122100

    KEGG: hsa:3859

    STRING: 9606.ENSP00000251643

    UniGene: Hs.66739



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