在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT12 Antibody, Biotin conjugated

  • 中文名稱:
    KRT12兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA859510LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KRT12 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CK-12 antibody; Cytokeratin-12 antibody; K12 antibody; K1C12_HUMAN antibody; Keratin 12 antibody; Keratin antibody; Keratin; type I cytoskeletal 12 antibody; Keratin-12 antibody; KRT12 antibody; type I cytoskeletal 12 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Keratin, type I cytoskeletal 12 protein (1-178AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in corneal epithelium organization, integrity and corneal keratin expression.
  • 基因功能參考文獻(xiàn):
    1. KC can co-exist with GCD. The missense mutation (c.370G > A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD. PMID: 28567551
    2. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals. PMID: 24801514
    3. We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea. PMID: 24099278
    4. The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein. PMID: 23222558
    5. The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 in the concentration ranges tested. PMID: 23233254
    6. Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family. PMID: 20577595
    7. Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy. PMID: 12543196
    8. A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families. PMID: 16227835
    9. Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy PMID: 16352477
    10. Mutation associated with symptomatic phenotype of Meesmann's corneal dystrophy. Results in substitution of proline for arginine in helix termination motif that may disrupt normal helix, leading to dramatic structural change of keratin 12 protein. PMID: 17653038
    11. This is the second family recently diagnosed with Meesmann dystrophy in Denmark. The family represents its own distinct genotype, independent of previously reported ones. All patients with microcysts were asymptomatic. PMID: 18245975
    12. The novel L433R mutation of the KRT12 gene found in two members of this Japanese family caused Meesmann corneal dystrophy (MECD). PMID: 18661274

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Corneal dystrophy, Meesmann (MECD)
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the corneal epithelium (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6414

    OMIM: 122100

    KEGG: hsa:3859

    STRING: 9606.ENSP00000251643

    UniGene: Hs.66739



主站蜘蛛池模板: 丁香五月激情综合国产| 天天av天天爽无码中文| 色综合色欲色综合色综合色综合r| 久久亚洲精品无码gv| 亚洲成_人网站图片| 好吊妞国产欧美日韩免费观看| 无码人妻一区二区三区精品视频| 色噜噜亚洲男人的天堂| 亚洲欧美中文字幕高清在线| 久久久亚洲一区二区三区| 午夜精品久久久久久久久久久久| 亚州中文字幕无码中文字幕| 国产成人精品亚洲精品| 欧美另类videossexo高潮| 亚洲精品久久久久久动漫器材一区| 一边啪啪的一边呻吟声口述 | 婷婷五月综合激情| 美女扒开尿口让男人桶| 免费网站看v片在线18禁无码| 欧美人妻少妇精品久久黑人| 国产内射爽爽大片视频社区在线 | 小荡货奶真大水多好紧视频| 色欲aⅴ 无码| 亚洲日韩aⅴ在线视频| 日本高清视频www| 伊人伊成久久人综合网996| 被黑人猛躁10次高潮视频| 蜜桃精品成人影片| 日本护士毛茸茸xx| 国产台湾无码av片在线观看| 国产亚洲视频中文字幕97精品 | 国产黄大片在线观看画质优化| 国产香蕉国产精品偷在线| 日本少妇浓毛bbwbbwbbw| 欧美又粗又大aaa片| 无码人妻一区二区三区免费| 丰满多毛的陰户视频| 亚洲人成电影网站在线观看| 丰满岳乱妇在线观看中字无码 | 欧美性猛交xxx嘿人猛交| 婷婷丁香六月激情综合啪|