在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT10 Antibody

  • 中文名稱:
    KRT10兔多克隆抗體
  • 貨號:
    CSB-PA012504GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BCIE antibody; BIE antibody; CK 10 antibody; CK-10 antibody; Cytokeratin-10 antibody; EHK antibody; K10 antibody; K1C10_HUMAN antibody; Keratin 10 antibody; Keratin 10 type I antibody; Keratin antibody; Keratin type i cytoskeletal 10 antibody; Keratin type I cytoskeletal 59 kDa antibody; Keratin-10 antibody; Keratin10 antibody; KPP antibody; KRT10 antibody; type I cytoskeletal 10 antibody
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human KRT10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
  • 基因功能參考文獻:
    1. The molecular diagnostics by the whole exome sequencing showed a novel de novo (c.1374-2A>C) mutation in the KRT10 gene responsible for the development of IWC (KRT10 defect was confirmed by immunofluorescent study). Concurrently, the m.14484T>C mutation in mitochondrial MTND6 gene (characteristic for Leber's hereditary optic neuropathy or LHON) was detected in patient, his mother and brother PMID: 28944608
    2. KRT10 gene mutation was present in all of the affected individuals, but absent in the five unaffected and 100 ethnically-matched healthy controls. PMID: 27212473
    3. Mutations in the highly conserved helix initiation motif of K10 were associated with mild or severe form of epidermolytic ichthyosis PMID: 26373619
    4. Report genetic/clinical spectrum of KRT10 mutations in keratinopathic ichthyosis. PMID: 26581228
    5. We present an autosomal dominant pedigree with epidermolytic ichthyosis resulting from a new heterozygous missense mutation in keratin 10. PMID: 26338057
    6. recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo PMID: 26125866
    7. findings provide structural insights into phenotypic variation in epidermolytic ichthyosis due to KRT10 mutations PMID: 26176760
    8. The diagnosis of ichthyosis with confetti was confirmed by the identification of 2 previously unreported mutations in intron 6 and exon 7 of KRT10. PMID: 24626314
    9. We present the spectrum of clinical variability of ichthyosis with confetti in 6 patients with confirmed mutations in KRT10. PMID: 25210931
    10. Case Report: extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis. PMID: 24096702
    11. Data indicate that KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer cells. PMID: 24434152
    12. Most of the orthokeratotic dysplasia constituent cells were immunopositive for keratin 10, but not for keratins 13, 17 or 19. PMID: 22734720
    13. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin play the role in pathogenesis of leprosy. PMID: 23121977
    14. Pneumococcal ligands K10, laminin receptor and platelet-activating factor receptor are elevated in aged lungs and contribute to the enhanced susceptibility to pneumonia. PMID: 21615674
    15. mapping and identifying disease-causing mutations in gene encoding KRT10 in ichthyosis with confetti; high frequency of somatic reversion suggests revertant stem cell clones are under positive selection and/or rate of mitotic recombination is elevated PMID: 20798280
    16. Data show that TIMP-1 and cytokeratin-10 were identified as 2 newly synthesized secreted proteins in PMID: 19904223
    17. Expression was altered in oral lichen planus lesions PMID: 19776502
    18. Mutations in codon 156 of K10, i.e. R156S, R156P, R156H were found in epidermolytic hyperkeratosis. PMID: 12234709
    19. cytokeratin 10 molecules were shown to be exposed on the surface of both desquamated nasal epithelial cells and keratinocytes; Staphylococcus aureus clumping factor B (ClfB) was shown to bind to cytokeratin K10 from the desquamated nasal epithelial cells PMID: 12427098
    20. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha is observed in transgenic mice expressing keratin K10 in the basal layer of the epidermis. PMID: 12566451
    21. normal cornified cell envelope is formed during the process of human epidermal keratinization, even if the suprabasal keratin filament network is disrupted as with this particular K10 mutation, M150T in BCIE PMID: 14705805
    22. cytokeratin 10 may have a role in progression of head and neck squamous cell carcinoma. PMID: 15254692
    23. We demonstrate that a recessive mutation in KRT10 leading to a complete human K10 knockout can cause EHK PMID: 16505000
    24. Candidate autoantigen in chronic, antibiotic-resistant Lyme arthritis. PMID: 16888010
    25. Squamous cell carcinoma (SCC) in mature cystic teratoma (MCT) expressed CK10 less frequently, but CK18 more frequently. SCC in MCT may be derived from metaplastic squamous epithelium. PMID: 17542994
    26. Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation. PMID: 18219278
    27. siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and K10 mRNAs PMID: 18259765
    28. CK10 alone, or in combination with CK19, can be a novel predictor for poor prognosis of hepatocellular carcinoma patients after curative resection. PMID: 18559605
    29. EHK is an autosomal dominant disorder of keratinization, caused by mutations in either the KRT1 or KRT10 genes. Our patient presents EHK with palmoplantar involvement and KRT10 mutation. PMID: 19443303
    30. premature termination codon of KRT10 maybe involved in recessive epidermolytic hyperkeratosis PMID: 19474805
    31. Infection by HPV may alter the differentiation status of the epidermis, leading to delayed or absent expression of cytokeratin 10. PMID: 19515043

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Epidermolytic hyperkeratosis (EHK); Ichthyosis annular epidermolytic (AEI); Erythroderma, ichthyosiform, congenital reticular (CRIE)
  • 亞細(xì)胞定位:
    Secreted, extracellular space. Cell surface.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6413

    OMIM: 113800

    KEGG: hsa:3858

    STRING: 9606.ENSP00000269576

    UniGene: Hs.99936



主站蜘蛛池模板: 青青草国产三级精品三级| 亚洲图片小说激情综合| 亚洲精品乱码久久久久久自慰| 日韩夜夜高潮夜夜爽无码| ww国产内射精品后入国产| 无码av免费毛片一区二区 | 久久精品人人做人人爱爱漫画 | 国产成人精品亚洲日本在线| 欧美丰满妇大ass| 97人人模人人爽人人少妇| 国产精品成人av在线观看春天| 国产伦子系列沙发午睡| 日本熟妇人妻videos| 亚洲精品无码专区在线| 一二三四区无产乱码1000集| 成人无码一区二区三区| 自拍区小说区图片区亚洲| 一边做一边喷17p亚洲乱妇50p| 嫩草国产露脸精品国产软件| 久久99精品国产麻豆宅宅| 成人3d动漫一区二区三区| 日韩精品无码人妻一区二区三区| 人妻无码手机在线中文| 欧美丰满熟妇bbb久久久| 中文乱码字慕人妻熟女人妻| 欧美日韩无套内射另类| 影音先锋无码a∨男人资源站| 午夜福利精品导航凹凸| 国产精品自在线拍国产手机版| 在线观看无码不卡av中文| 亚洲精品综合欧美一区二区三区 | 亚洲精品一线二线三线区别大吗 | 国产精品亚洲精品日韩已满| 亚洲精品久久一区二区无卡| 亚洲人成网7777777国产| 中文字幕亚洲乱码熟女在线 | 双腿张开被9个黑人调教影片| 欧美日韩人成视频在线播放| 农村乱人伦一区二区| 亚洲午夜成人片| 真人祼交二十三式视频|