在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT10 Antibody

  • 中文名稱:
    KRT10兔多克隆抗體
  • 貨號:
    CSB-PA012504LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KRT10 antibody at 6µg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA012504LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012504LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA012504LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA012504LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KRT10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BCIE antibody; BIE antibody; CK 10 antibody; CK-10 antibody; Cytokeratin-10 antibody; EHK antibody; K10 antibody; K1C10_HUMAN antibody; Keratin 10 antibody; Keratin 10 type I antibody; Keratin antibody; Keratin type i cytoskeletal 10 antibody; Keratin type I cytoskeletal 59 kDa antibody; Keratin-10 antibody; Keratin10 antibody; KPP antibody; KRT10 antibody; type I cytoskeletal 10 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Keratin, type I cytoskeletal 10 protein (1-584AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,KRT10 Antibody (CSB-PA012504LA01HU),的標記方式是Non-conjugated。對于KRT10 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA012504LB01HU KRT10 Antibody, HRP conjugated ELISA
    FITC CSB-PA012504LC01HU KRT10 Antibody, FITC conjugated
    Biotin CSB-PA012504LD01HU KRT10 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
  • 基因功能參考文獻:
    1. The molecular diagnostics by the whole exome sequencing showed a novel de novo (c.1374-2A>C) mutation in the KRT10 gene responsible for the development of IWC (KRT10 defect was confirmed by immunofluorescent study). Concurrently, the m.14484T>C mutation in mitochondrial MTND6 gene (characteristic for Leber's hereditary optic neuropathy or LHON) was detected in patient, his mother and brother PMID: 28944608
    2. KRT10 gene mutation was present in all of the affected individuals, but absent in the five unaffected and 100 ethnically-matched healthy controls. PMID: 27212473
    3. Mutations in the highly conserved helix initiation motif of K10 were associated with mild or severe form of epidermolytic ichthyosis PMID: 26373619
    4. Report genetic/clinical spectrum of KRT10 mutations in keratinopathic ichthyosis. PMID: 26581228
    5. We present an autosomal dominant pedigree with epidermolytic ichthyosis resulting from a new heterozygous missense mutation in keratin 10. PMID: 26338057
    6. recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo PMID: 26125866
    7. findings provide structural insights into phenotypic variation in epidermolytic ichthyosis due to KRT10 mutations PMID: 26176760
    8. The diagnosis of ichthyosis with confetti was confirmed by the identification of 2 previously unreported mutations in intron 6 and exon 7 of KRT10. PMID: 24626314
    9. We present the spectrum of clinical variability of ichthyosis with confetti in 6 patients with confirmed mutations in KRT10. PMID: 25210931
    10. Case Report: extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis. PMID: 24096702
    11. Data indicate that KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer cells. PMID: 24434152
    12. Most of the orthokeratotic dysplasia constituent cells were immunopositive for keratin 10, but not for keratins 13, 17 or 19. PMID: 22734720
    13. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin play the role in pathogenesis of leprosy. PMID: 23121977
    14. Pneumococcal ligands K10, laminin receptor and platelet-activating factor receptor are elevated in aged lungs and contribute to the enhanced susceptibility to pneumonia. PMID: 21615674
    15. mapping and identifying disease-causing mutations in gene encoding KRT10 in ichthyosis with confetti; high frequency of somatic reversion suggests revertant stem cell clones are under positive selection and/or rate of mitotic recombination is elevated PMID: 20798280
    16. Data show that TIMP-1 and cytokeratin-10 were identified as 2 newly synthesized secreted proteins in PMID: 19904223
    17. Expression was altered in oral lichen planus lesions PMID: 19776502
    18. Mutations in codon 156 of K10, i.e. R156S, R156P, R156H were found in epidermolytic hyperkeratosis. PMID: 12234709
    19. cytokeratin 10 molecules were shown to be exposed on the surface of both desquamated nasal epithelial cells and keratinocytes; Staphylococcus aureus clumping factor B (ClfB) was shown to bind to cytokeratin K10 from the desquamated nasal epithelial cells PMID: 12427098
    20. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha is observed in transgenic mice expressing keratin K10 in the basal layer of the epidermis. PMID: 12566451
    21. normal cornified cell envelope is formed during the process of human epidermal keratinization, even if the suprabasal keratin filament network is disrupted as with this particular K10 mutation, M150T in BCIE PMID: 14705805
    22. cytokeratin 10 may have a role in progression of head and neck squamous cell carcinoma. PMID: 15254692
    23. We demonstrate that a recessive mutation in KRT10 leading to a complete human K10 knockout can cause EHK PMID: 16505000
    24. Candidate autoantigen in chronic, antibiotic-resistant Lyme arthritis. PMID: 16888010
    25. Squamous cell carcinoma (SCC) in mature cystic teratoma (MCT) expressed CK10 less frequently, but CK18 more frequently. SCC in MCT may be derived from metaplastic squamous epithelium. PMID: 17542994
    26. Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation. PMID: 18219278
    27. siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and K10 mRNAs PMID: 18259765
    28. CK10 alone, or in combination with CK19, can be a novel predictor for poor prognosis of hepatocellular carcinoma patients after curative resection. PMID: 18559605
    29. EHK is an autosomal dominant disorder of keratinization, caused by mutations in either the KRT1 or KRT10 genes. Our patient presents EHK with palmoplantar involvement and KRT10 mutation. PMID: 19443303
    30. premature termination codon of KRT10 maybe involved in recessive epidermolytic hyperkeratosis PMID: 19474805
    31. Infection by HPV may alter the differentiation status of the epidermis, leading to delayed or absent expression of cytokeratin 10. PMID: 19515043

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Epidermolytic hyperkeratosis (EHK); Ichthyosis annular epidermolytic (AEI); Erythroderma, ichthyosiform, congenital reticular (CRIE)
  • 亞細胞定位:
    Secreted, extracellular space. Cell surface.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6413

    OMIM: 113800

    KEGG: hsa:3858

    STRING: 9606.ENSP00000269576

    UniGene: Hs.99936



主站蜘蛛池模板: 亚洲男同gv在线观看| 欧美黑人又粗又大高潮喷水| 国产拍拍拍无码视频免费 | 亚洲va久久久噜噜噜久久4399| 中文乱码字幕高清一区二区| 公与淑婷厨房猛烈进出视频免费| 性少妇无码播放| 蜜桃av抽搐高潮一区二区| 丰满岳乱妇一区二区三区| 蜜桃视频韩日免费播放| 香蕉在线 亚洲 欧美 专区| 一本大道东京热无码一区| 自愉自愉产区二十四区| 久久人人97超碰国产亚洲人| 九九视频麻婆豆腐在线观看| 老色69久久九九精品高潮| 人人妻人人澡人人爽人人精品av | 一本一道波多野结衣av黑人| 高清国产亚洲精品自在久久| 国产 av 仑乱内谢| 在线а√天堂中文官网| 国产成人久久精品二区三区| www国产精品内射| 中文无码一区二区视频在线播放量| 国产精品18久久久久久欧美| 欧美情侣性视频| 亚洲妓女综合网99| 人妻三级日本香港三级极| 永久黄网站色视频免费看| 人妻 校园 激情 另类| 日韩va中文字幕无码电影| 天天躁夜夜踩很很踩2022| 中文乱码字幕高清一区二区| 国产av一区二区精品久久凹凸 | 国产精品sp调教打屁股| 九九热线精品视频16| 成人做爰www网站视频下载| 国内精品久久毛片一区二区| 国产精品丝袜久久久久久不卡| 热の综合热の国产热の潮在线| 精品无码人妻一区二区免费蜜桃|