在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KPNA4 Antibody

KPNA4 Antibody

  • 中文名稱：
    KPNA4兔多克隆抗體
  • 貨號：
    CSB-PA012486GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KPNA4
  • 別名：
    FLJ31113 antibody; IMA3_HUMAN antibody; Importin alpha 3 antibody; Importin alpha 4 subunit antibody; Importin alpha Q1 antibody; Importin subunit alpha 3 antibody; Importin subunit alpha-3 antibody; IPO A3 antibody; IPOA 3 antibody; IPOA3 antibody; Karyopherin alpha 4 (importin alpha 3) antibody; Karyopherin alpha 4 antibody; Karyopherin alpha 4 importin alpha 3 antibody; Karyopherin alpha 4 subunit antibody; Karyopherin subunit alpha 4 antibody; Karyopherin subunit alpha-4 antibody; KPNA 4 antibody; Kpna4 antibody; MGC12217 antibody; MGC26703 antibody; OTTHUMP00000213880 antibody; QIP 1 antibody; Qip1 antibody; Qip1 protein antibody; SRP 3 antibody; SRP3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KPNA4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
  • 基因功能參考文獻：
    1. Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. PMID: 29042532
    2. Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4. PMID: 28000015
    3. Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b. PMID: 26283154
    4. upon DNA damage transport adaptor importin-alpha4 imports XPA into the nucleus in an ATR-dependent manner. PMID: 23861882
    5. Importin alpha3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. PMID: 23383277
    6. Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication. PMID: 20554775
    7. stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import PMID: 19927155
    8. Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in cells overexpressing PHB. PMID: 19710421
    9. Our results indicate that the nuclear import of RHA is mediated by the importin-alpha3/importin-beta-dependent pathway and suggest that the specificity for importin may regulate the functions of cargo proteins. PMID: 16375861
    10. Daxx interacts selectively with importin alpha3 through its NLS1 and NLS2 sequences. Conversely, importin alpha3 utilizes two NLS-binding sites for Daxx interaction, suggesting that it mediates nuclear import of Daxx. PMID: 17661348

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin alpha family
  • 組織特異性：
    Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 6397

    OMIM: 602970

    KEGG: hsa:3840

    STRING: 9606.ENSP00000334373

    UniGene: Hs.467866



主站蜘蛛池模板： 国产凹凸在线一区二区| 久久―日本道色综合久久| 国产精品久久久天天影视香蕉| 在线成人精品国产区免费| 亚洲精品成人无限看| 国产成人 综合 亚洲欧洲| av无码久久久久不卡网站下载| 亚洲精品久久久狠狠爱小说| 精品不卡一区二区| 亚洲婷婷综合色香五月| 亚洲精品国产自在现线最新| 少妇久久久久久被弄高潮 | 在线成人a毛片免费播放| 亚洲中文无码永久免| 精品国产一区二区三区久久久狼| 日韩欧美人妻一区二区三区| 成年片色大黄全免费软件到| 亚洲不卡一卡2卡三卡4卡5卡 | 国产精品国产高清国产av| 亚洲第一成人网站在线播放| 国产免费人成在线视频网站| 四虎成人精品一区二区免费网站| 久久人人爽天天玩人人妻精品| 97碰碰碰免费公开在线视频 | 亚洲精品第一国产综合精品| 鲁鲁夜夜天天综合视频| 色妞www精品视频| 精品黑人一区二区三区| 国产99青草视频在线播放视| 婷婷综合缴情亚洲狠狠小说| 色翁荡熄又大又硬又粗又视频| 黄网站色视频免费国产| 亚洲精品中文字幕乱码4区| 欧洲极品少妇| 欧美人与禽猛交狂配| 亚洲h成年动漫在线观看网站| 亚洲另类激情综合偷自拍图| 欧美疯狂性受xxxxx喷水| 男女啪啪无遮挡免费网站| 亚洲一区在线观看尤物| 女人18毛片水真多|