在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KPNA4 Antibody

KPNA4 Antibody

  • 中文名稱：
    KPNA4兔多克隆抗體
  • 貨號：
    CSB-PA012486GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KPNA4
  • 別名：
    FLJ31113 antibody; IMA3_HUMAN antibody; Importin alpha 3 antibody; Importin alpha 4 subunit antibody; Importin alpha Q1 antibody; Importin subunit alpha 3 antibody; Importin subunit alpha-3 antibody; IPO A3 antibody; IPOA 3 antibody; IPOA3 antibody; Karyopherin alpha 4 (importin alpha 3) antibody; Karyopherin alpha 4 antibody; Karyopherin alpha 4 importin alpha 3 antibody; Karyopherin alpha 4 subunit antibody; Karyopherin subunit alpha 4 antibody; Karyopherin subunit alpha-4 antibody; KPNA 4 antibody; Kpna4 antibody; MGC12217 antibody; MGC26703 antibody; OTTHUMP00000213880 antibody; QIP 1 antibody; Qip1 antibody; Qip1 protein antibody; SRP 3 antibody; SRP3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KPNA4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
  • 基因功能參考文獻：
    1. Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. PMID: 29042532
    2. Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4. PMID: 28000015
    3. Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b. PMID: 26283154
    4. upon DNA damage transport adaptor importin-alpha4 imports XPA into the nucleus in an ATR-dependent manner. PMID: 23861882
    5. Importin alpha3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. PMID: 23383277
    6. Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication. PMID: 20554775
    7. stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import PMID: 19927155
    8. Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in cells overexpressing PHB. PMID: 19710421
    9. Our results indicate that the nuclear import of RHA is mediated by the importin-alpha3/importin-beta-dependent pathway and suggest that the specificity for importin may regulate the functions of cargo proteins. PMID: 16375861
    10. Daxx interacts selectively with importin alpha3 through its NLS1 and NLS2 sequences. Conversely, importin alpha3 utilizes two NLS-binding sites for Daxx interaction, suggesting that it mediates nuclear import of Daxx. PMID: 17661348

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin alpha family
  • 組織特異性：
    Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 6397

    OMIM: 602970

    KEGG: hsa:3840

    STRING: 9606.ENSP00000334373

    UniGene: Hs.467866



主站蜘蛛池模板： 97精品一区二区视频在线观看| 国产精品人妻熟女男人的天堂 | 久久99精品久久久久蜜芽| 免费做a爰片久久毛片a片| 97午夜理论片在线影院| 九九热线有精品视频| 天堂岛国av无码免费无禁网站| 成人无码av一区二区| 国产精品无码人妻一区二区在线| 日韩人妻无码制服丝袜视频| 亚洲国产精品第一区二区三区 | 日韩精品中文字幕无码一区| 真实国产乱子伦精品一区二区三区| 蜜桃少妇av久久久久久久| 亚洲色精品aⅴ一区区三区| 在线观看国产精品电影| 无码动漫性爽xo视频在线观看| 日韩一区二区三区四区区区| 亚洲精品天堂成人片av在线播放 | 久久久久99精品成人片牛牛影视| 狼友网精品视频在线观看| 一本大道东京热无码| 男女裸交免费无遮挡全过程| 欧美乱强伦xxxxx高潮| 亚洲伊人久久成人综合网| 亚洲综合图色40p| а√天堂资源中文在线官网| 成人影院永久免费观看网址| gv天堂gv无码男同在线观看| 99这里只有精品| www激情内射在线看| 国产精品va在线播放| 少妇私密会所按摩到高潮呻吟| 欧美不卡一卡二卡三卡| 亚洲无线码中文字幕在线| 亚洲一区二区三区偷拍女厕| 国产精品无码一区二区三区 | av性色在线乱叫| 99re久久精品国产| 中文精品久久久久人妻| 久久人人97超碰国产精品|