在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KMT2B Antibody

  • 中文名稱:
    KMT2B兔多克隆抗體
  • 貨號(hào):
    CSB-PA890939LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of Hela cells with CSB-PA890939LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KMT2B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KMT2B
  • 別名:
    Histone-lysine N-methyltransferase 2B antibody; HRX2 antibody; KIAA0304 gene product antibody; KMT2B antibody; KMT2B_HUMAN antibody; Likely ortholog of mouse WW domain binding protein 7 antibody; Lysine N-methyltransferase 2B antibody; mixed lineage leukemia 4 antibody; Mixed lineage leukemia gene homolog 2 protein antibody; MLL2 antibody; myeloid lymphoid leukemia 4 antibody; Myeloid lymphoid or mixed lineage leukemia protein 4 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 4 antibody; Trithorax homolog 2 antibody; trithorax homologue 2 antibody; TRX2 antibody; WBP-7 antibody; WBP7 antibody; WW domain-binding protein 7 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Histone-lysine N-methyltransferase 2B protein (145-290AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,KMT2B Antibody (CSB-PA890939LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于KMT2B Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA890939LB01HU KMT2B Antibody, HRP conjugated ELISA
    FITC CSB-PA890939LC01HU KMT2B Antibody, FITC conjugated
    Biotin CSB-PA890939LD01HU KMT2B Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
  • 基因功能參考文獻(xiàn):
    1. Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex. PMID: 28976802
    2. Summary of variants in KMT2B associated with dystonia, as well as the clinical phenotype (review) PMID: 29289525
    3. Rare missense variation in KMT2B represents an additional cause of generalized dystonia. PMID: 28520167
    4. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
    5. we describe a method to seamlessly modify a putative CDK2 phosphorylation site on MLL2 to restrict its phosphorylation and activation. Specifically, by utilizing dimeric CRISPR RNA-guided nucleases, RFNs (commercially known as the NextGENtrade mark CRISPR), in combination with an excision-only piggyBactrade mark transposase, we demonstrate how to generate a point mutation of threonine-542, a predicted site to prevent M... PMID: 27075976
    6. The crucial role of KMT2B in the physiological control of voluntary movement. PMID: 27992417
    7. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer. PMID: 28124401
    8. Results show that KMT2B interacts with ERalpha to bind the ERalpha-binding sites of IL-20 and other ERalpha target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20, and other ERalpha-responsive genes, in breast cancer cells. PMID: 27806114
    9. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B; moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis PMID: 27839873
    10. The results explain how the MLL SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 lysine. PMID: 26320581
    11. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
    12. We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. PMID: 26180087
    13. HBV-MLL4 integration occurred frequently in Chinese HCC patients, representing a unique molecular segment for HCC with HBV infection PMID: 25901726
    14. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth. PMID: 25139254
    15. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation. PMID: 23426673
    16. knockdown of MLL4 severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells. PMID: 22713656
    17. Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2 PMID: 19060922
    18. data suggest that the translocation breakpoint of MLL4 gene is one of the preferential targets for HBV DNA integration into the MLL4 gene and the HBV DNA integration may be involved in liver oncogenesis PMID: 18320596

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
  • 組織特異性:
    Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocyte
  • 數(shù)據(jù)庫鏈接:

    HGNC: 15840

    OMIM: 606834

    KEGG: hsa:9757

    STRING: 9606.ENSP00000222270

    UniGene: Hs.676457



主站蜘蛛池模板: 狠狠色综合7777久夜色撩人ⅰ| 伊人久久大香线蕉影院| 国外亚洲成av人片在线观看| 高潮毛片又色又爽免费| 日韩av无码成人无码免费 | 捆绑白丝粉色jk震动捧喷白浆| 日日碰狠狠添天天爽五月婷| 2022国产日产欧产精品| 国产成人精品久久| 欧美性生交xxxxx久久久| 亚洲人成网站在线无码| 四虎影库久免费视频| 日韩夜夜高潮夜夜爽无码| 欧美国产日产一区二区| 亚洲a综合一区二区三区| 日本免费高清一本视频| 亚洲人成电影网站色www两男一女| 国产探花在线精品一区二区| 国产日产欧产精品精品ai| 2018年秋霞无码片 | 小荡货好紧好爽奶头大视频| 日本特黄特色特爽大片| av在线 高清不卡区| 国产很色很黄很大爽的视频| 国产精品网站在线观看免费传媒| 国产成人a人亚洲精品无码| 国产亚洲999精品aa片在线爽| 久青青视频在线观看久| 女人爽到高潮免费视频大全| 永久免费观看黄网视频| 欧美成人www免费全部网站| 胸大美女又黄的网站| 久久er热在这里只有精品66| 任我橹这里只有精品 在线视频| 毛片免费视频在线观看| 国产亲子乱弄免费视频| 亚洲中文字幕乱码一区| 国产成人无码a区在线观看视频| 国产96在线 | 欧美| av毛片无码中文字幕不卡| 少妇高潮喷水惨叫久久久久电影|