在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KMT2B Antibody

  • 中文名稱:
    KMT2B兔多克隆抗體
  • 貨號:
    CSB-PA590426
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/40.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KMT2B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KMT2B
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide corresponding to residues near the N terminal of Human lysine (K)-specific methyltransferase 2D
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
  • 基因功能參考文獻:
    1. Gene silencing experiments of MLL4 and the subunits PA1 and PTIP confirm TGF-beta-specific genes to be regulated by the MLL4 complex, which links TGF-beta signaling to transcription regulation by the MLL4 methyltransferase complex. PMID: 28976802
    2. Summary of variants in KMT2B associated with dystonia, as well as the clinical phenotype (review) PMID: 29289525
    3. Rare missense variation in KMT2B represents an additional cause of generalized dystonia. PMID: 28520167
    4. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
    5. we describe a method to seamlessly modify a putative CDK2 phosphorylation site on MLL2 to restrict its phosphorylation and activation. Specifically, by utilizing dimeric CRISPR RNA-guided nucleases, RFNs (commercially known as the NextGENtrade mark CRISPR), in combination with an excision-only piggyBactrade mark transposase, we demonstrate how to generate a point mutation of threonine-542, a predicted site to prevent M... PMID: 27075976
    6. The crucial role of KMT2B in the physiological control of voluntary movement. PMID: 27992417
    7. MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer. PMID: 28124401
    8. Results show that KMT2B interacts with ERalpha to bind the ERalpha-binding sites of IL-20 and other ERalpha target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20, and other ERalpha-responsive genes, in breast cancer cells. PMID: 27806114
    9. findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B; moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis PMID: 27839873
    10. The results explain how the MLL SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 lysine. PMID: 26320581
    11. The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes. PMID: 26267306
    12. We propose that MLL3 and MLL4 are broadly required for controlling MAFA and MAFB transactivation during development and postnatally. PMID: 26180087
    13. HBV-MLL4 integration occurred frequently in Chinese HCC patients, representing a unique molecular segment for HCC with HBV infection PMID: 25901726
    14. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth. PMID: 25139254
    15. KMT2B transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation. PMID: 23426673
    16. knockdown of MLL4 severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells. PMID: 22713656
    17. Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2 PMID: 19060922
    18. data suggest that the translocation breakpoint of MLL4 gene is one of the preferential targets for HBV DNA integration into the MLL4 gene and the HBV DNA integration may be involved in liver oncogenesis PMID: 18320596

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
  • 組織特異性:
    Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocyte
  • 數據庫鏈接:

    HGNC: 15840

    OMIM: 606834

    KEGG: hsa:9757

    STRING: 9606.ENSP00000222270

    UniGene: Hs.676457



主站蜘蛛池模板: 伊人久久大香线蕉av成人| 在线 无码 中文字幕 强 乱| 久久五十路丰满熟女中出| 最新在线精品国产福利| 久久无码人妻一区二区三区午夜| 女被男啪到哭的视频网站 | 激情爆乳一区二区三区| 好硬好湿好爽再深一点动态图视频| 亚洲国产成人无码网站大全| 亚洲综合色丁香婷婷六月图片| 国产成人92精品午夜福利| 亚洲熟妇av综合网五月| 四虎永久地址www成人| 中文字幕精品无码一区二区| 色妺妺免费影院| 亚洲跨种族黑人xxxxx| 国产免费mv大片人人电影播放器| 麻豆av传媒蜜桃天美传媒| 亚洲熟妇av一区二区三区宅男| 顶级少妇做爰视频在线观看| 亚洲日韩乱码久久久久久| 宅男66lu国产在线观看| 国产高潮流白浆视频| 国产在线一区二区香蕉 在线| 夜夜夜夜曰天天天天拍国产| 特级a做爰全过程片| 亚洲伊人情人综合网站| 色噜噜狠狠狠狠色综合久一 | 精品人妻系列无码人妻漫画| 少妇愉情理伦片丰满丰满午夜| 国产好吊看视频在线观看| 18禁黄网站男男禁片免费观看| 亚洲日韩v无码中文字幕| 无码手机线免费观看| 亚洲精品99久久久久久欧美版| 人妻无码一区二区三区| 久久精品国产曰本波多野结衣| 香蕉久久国产超碰青草| 五月婷婷久久草丁香| 黄瓜视频在线观看| 久久久久99精品成人品|