在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLK14 Antibody

  • 中文名稱:
    KLK14兔多克隆抗體
  • 貨號:
    CSB-PA147162
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA147162(KLK14 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA147162(KLK14 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: CSB-PA147162(KLK14 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KLK14
  • 別名:
    hK14 antibody; Kallikrein 14 antibody; Kallikrein like protein 6 antibody; Kallikrein-14 antibody; Kallikrein-like protein 6 antibody; KLK L6 antibody; KLK-L6 antibody; KLK14 antibody; KLK14_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human KLK14
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
  • 基因功能參考文獻:
    1. There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. High KLK14 mRNA levels were significantly associated with prolonged PFS (HR = 0.44, P = 0.017) and showed a trend towards significance for OS (HR = 0.55, P = 0.070). PMID: 29546479
    2. increased KLK14 activity could contribute at multiple levels to HGF/Met-mediated processes in prostate and other cancers PMID: 27533117
    3. KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients. PMID: 23224034
    4. genetic variants in the KLK14 locus are associated with risk and/or aggressiveness of prostate cancer PMID: 22505522
    5. KLK14, acting via PAR-2, represents an autocrine/paracrine regulator of colon tumorigenesis PMID: 22505523
    6. KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies. PMID: 21057706
    7. The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. PMID: 20155713
    8. KLK14 overexpression was found to be a significant predictor of decreased disease-free survival and overall survival in breast cancer patients PMID: 12439719
    9. KLK14 expression upregulated in advanced and more aggressive prostate tumors; may play role in tumor spread and may be new marker for prostate cancer diagnosis and prognosis PMID: 12858357
    10. may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance. PMID: 15654974
    11. hK14 has dual activity, trypsin- and chymotrypsin-like, with a preference for cleavage after arginine residues PMID: 15843175
    12. KLK14 is clearly overexpressed in breast cancer in comparison to normal breast tissues and is positively associated with conventional parameters of tumour aggressiveness PMID: 16434994
    13. The majority of KLK14 in the plantar stratum corneum is present in its catalytically active form. KLK14 could be immunohistochemically detected in sweat ducts, preferentially in the intraepidermal parts (the acrosyringium), and in sweat glands. PMID: 16800737
    14. KLK14 may be implicated in several facets of tumor progression, including growth, invasion, and angiogenesis, as well as in arthritic disease via deterioration of cartilage PMID: 17110383
    15. KLK14 may participate in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor (LEKTI). PMID: 17158887
    16. KLK14 is a new activator component of the KLK proteolytic cascade with a possible role in seminal plasma and skin PMID: 18056261
    17. semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity. PMID: 18482984
    18. Expression of the KLK14 protein correlated with the pathological tumor status in prostate cancer and was associated with disease progression defined by prostate-specific antigen relapse in univariate Kaplan-Meier analysis. PMID: 18497543
    19. positive staining was significantly associated with NSCLC adenocarcinoma histotype (KLK13, p=0.014) and tumor size (KLK14, p=0.048) PMID: 18627302
    20. KLK4 is only expressed in breast and prostate cancers that express the progesterone receptor (PR) and androgen receptor (AR), respectively. PMID: 19147544

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin
  • 數據庫鏈接:

    HGNC: 6362

    OMIM: 606135

    KEGG: hsa:43847

    STRING: 9606.ENSP00000156499

    UniGene: Hs.283925



主站蜘蛛池模板: 国产美女自卫慰水免费视频| 亚洲蜜桃v妇女| 欧美成人午夜精品久久久| 久久久午夜精品福利内容| 久久精品人妻一区二区三区| 麻豆ā片免费观看在线看| 亚洲精品久久久久国产剧8| 成人爽a毛片免费| 欧美成人精品手机在线| 免费无码av片在线观看潮喷| 日本少妇xxxx做受| 狠狠色色综合网站| 超碰人人超碰人人| 男人女人午夜视频免费| 亚洲精品欧美精品日韩精品| 无线乱码一二三区免费看| 久久久久亚洲精品中文字幕| 久久精品国产亚洲精品| 日本少妇肉体裸交xxx| 久久綾合久久鬼色88| 深夜爽爽动态图无遮无挡| 国产偷国产偷亚洲高清app| 人妻激情偷乱视频一区二区三区| 亚洲国产制服丝袜无码av| 亚洲偷精品国产五月丁香麻豆| 日本三级香港三级三级人!妇久 | 蜜桃av无码免费看永久| 精品无人乱码高清在线观看| 人妻激情文学| 初尝人妻少妇中文字幕| 色婷婷五月综合久久| 久久综合国产乱子伦精品免费 | 国产精品成人va在线观看| 四虎永久在线精品免费视频观看| 国产午夜亚洲精品国产成人| 天堂а√在线中文在线最新版| 久久久精品国产sm调教网站| 久久久橹橹橹久久久久高清| 亚洲国产精品无码中文字| 久久久久成人片免费观看蜜芽| 综合色区亚洲熟妇另类|