在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Kallikrein-14(KLK14) ELISA kit

  • 中文名稱:
    人激肽釋放酶-14(KLK14)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL012451HU
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人激肽釋放酶-14(KLK14)酶聯(lián)免疫試劑盒(CSB-EL012451HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的KLK14含量。KLK14是一種重要靶點。它屬于激肽釋放酶家族成員,在人體生理和病理過程中發(fā)揮作用。研究機制上,其參與多種細胞信號通路的調(diào)節(jié),與腫瘤發(fā)生、發(fā)展及轉(zhuǎn)移等密切相關(guān),有望成為疾病診斷標志物和治療的新靶點。試劑盒檢測范圍為1.56 ng/ml-100 ng/ml,為科研人員研究KLK14在疾病模型中的表達調(diào)控、探索其作為生物標志物的潛力,或評估藥物干預(yù)對相關(guān)通路的影響提供可靠工具,廣泛應(yīng)用于腫瘤學(xué)、免疫學(xué)及分子病理學(xué)等基礎(chǔ)研究領(lǐng)域本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    hK14 ELISA Kit; Kallikrein 14 ELISA Kit; Kallikrein like protein 6 ELISA Kit; Kallikrein-14 ELISA Kit; Kallikrein-like protein 6 ELISA Kit; KLK L6 ELISA Kit; KLK-L6 ELISA Kit; KLK14 ELISA Kit; KLK14_HUMAN ELISA Kit
  • 縮寫:
    KLK14
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    1.56 ng/ml-100 ng/ml
  • 靈敏度:
    0.39 ng/ml
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cancer
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能:
    Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis.
  • 基因功能參考文獻:
    1. There was no significant association of KLK13 and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. High KLK14 mRNA levels were significantly associated with prolonged PFS (HR = 0.44, P = 0.017) and showed a trend towards significance for OS (HR = 0.55, P = 0.070). PMID: 29546479
    2. increased KLK14 activity could contribute at multiple levels to HGF/Met-mediated processes in prostate and other cancers PMID: 27533117
    3. KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients. PMID: 23224034
    4. genetic variants in the KLK14 locus are associated with risk and/or aggressiveness of prostate cancer PMID: 22505522
    5. KLK14, acting via PAR-2, represents an autocrine/paracrine regulator of colon tumorigenesis PMID: 22505523
    6. KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies. PMID: 21057706
    7. The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland. PMID: 20155713
    8. KLK14 overexpression was found to be a significant predictor of decreased disease-free survival and overall survival in breast cancer patients PMID: 12439719
    9. KLK14 expression upregulated in advanced and more aggressive prostate tumors; may play role in tumor spread and may be new marker for prostate cancer diagnosis and prognosis PMID: 12858357
    10. may be part of a protease cascade in the stratum corneum, and that the observed pH effects may have physiological relevance. PMID: 15654974
    11. hK14 has dual activity, trypsin- and chymotrypsin-like, with a preference for cleavage after arginine residues PMID: 15843175
    12. KLK14 is clearly overexpressed in breast cancer in comparison to normal breast tissues and is positively associated with conventional parameters of tumour aggressiveness PMID: 16434994
    13. The majority of KLK14 in the plantar stratum corneum is present in its catalytically active form. KLK14 could be immunohistochemically detected in sweat ducts, preferentially in the intraepidermal parts (the acrosyringium), and in sweat glands. PMID: 16800737
    14. KLK14 may be implicated in several facets of tumor progression, including growth, invasion, and angiogenesis, as well as in arthritic disease via deterioration of cartilage PMID: 17110383
    15. KLK14 may participate in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor (LEKTI). PMID: 17158887
    16. KLK14 is a new activator component of the KLK proteolytic cascade with a possible role in seminal plasma and skin PMID: 18056261
    17. semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity. PMID: 18482984
    18. Expression of the KLK14 protein correlated with the pathological tumor status in prostate cancer and was associated with disease progression defined by prostate-specific antigen relapse in univariate Kaplan-Meier analysis. PMID: 18497543
    19. positive staining was significantly associated with NSCLC adenocarcinoma histotype (KLK13, p=0.014) and tumor size (KLK14, p=0.048) PMID: 18627302
    20. KLK4 is only expressed in breast and prostate cancers that express the progesterone receptor (PR) and androgen receptor (AR), respectively. PMID: 19147544

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted, extracellular space.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6362

    OMIM: 606135

    KEGG: hsa:43847

    STRING: 9606.ENSP00000156499

    UniGene: Hs.283925



主站蜘蛛池模板: av无码东京热亚洲男人的天堂| 亲嘴扒胸摸屁股激烈网站 | 国产精品日本亚洲欧美| 国产精品人人做人人爽人人添| 精品夜夜爽欧美毛片视频| 色婷婷六月亚洲婷婷丁香| 成人污污污www网站免费| 欧美黑人又粗又大的性格特点| 蜜臀久久99精品久久久久久| 欧美人与动牲交zooz男人| 四库影院永久国产精品地址| 国产无遮挡18禁无码网站免费| 精品无码国产av一区二区| 国产成人免费97在线| 大胸美女污污污www网站| 无码视频一区二区三区 | 日韩伦人妻无码| av片日韩一区二区三区在线观看| 久久ww精品w免费人成| 夜夜高潮夜夜爽高清完整版1| 国产精品爱啪在线播放| 国产理论剧情大片在线播放| 18黄暴禁片在线观看| 日韩国产丝袜人妻一二区| 国产成人一区二区三区别| 国产末成年av在线播放| 日韩a人毛片精品无人区乱码| www夜片内射视频在观看视频| 人人妻人人爽人人做夜欢视频| 中文av岛国无码免费播放| 公与淑婷厨房猛烈进出视频免费| 精品国产av 无码一区二区三区| 奇米精品视频一区二区三区| 国精品午夜福利视频| 国产成人高清精品亚洲| 天堂а√中文在线官网| 国产成人久久综合77777| 欧洲国产精品无码专区影院| 国产成人一区二区三区在线| 国产jjzzjjzz视频全部免费| 国产午夜鲁丝片av无码免费|