在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLK11 Antibody

  • 中文名稱:
    KLK11兔多克隆抗體
  • 貨號:
    CSB-PA562259
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA562259(KLK11 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KLK11
  • 別名:
    Hippostasin antibody; hK11 antibody; Kallikrein 11 antibody; Kallikrein 11 isoform 1 preproprotein antibody; Kallikrein 11 isoform 2 precursor antibody; Kallikrein 11 precursor antibody; Kallikrein related peptidase 11 antibody; Kallikrein-11 inactive chain 2 antibody; KLK 11 antibody; Klk11 antibody; KLK11_HUMAN antibody; MGC33060 antibody; Protease serine 20 trypsin like antibody; Protease serine trypsin like antibody; PRSS20 antibody; Serine protease 20 antibody; TLSP antibody; Trypsin like protease antibody; Trypsin-like protease antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human KLK11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • 基因功能參考文獻:
    1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    2. Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
    3. KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma PMID: 25123036
    4. hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. PMID: 24169449
    5. The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. PMID: 24288670
    6. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. PMID: 23639975
    7. HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients PMID: 23647300
    8. Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. PMID: 23602830
    9. Patients harboring KLK11-positive tumors had a significantly decreased risk of death. PMID: 22429520
    10. Low KLK11 protein expression is associated with gastric cancer. PMID: 21618246
    11. For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones PMID: 21520985
    12. the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. PMID: 19242826
    13. hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. PMID: 19184568
    14. Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. PMID: 19560453
    15. may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy PMID: 11550212
    16. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. PMID: 11782391
    17. Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions. PMID: 12539228
    18. There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade. PMID: 12736044
    19. hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer PMID: 12845660
    20. KLK11 expression may play an important role in ovarian cancer development PMID: 15102682
    21. Kallikrein 11 is an independent marker of favorable prognosis in ovarian cancer patients. PMID: 15329323
    22. KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples PMID: 15893744
    23. results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
    24. The gene promoter regions of kallikrein and the corresponding transcriptional initiation sites were studied. PMID: 16911518
    25. The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
    26. Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. PMID: 19190824
    27. synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • 數據庫鏈接:

    HGNC: 6359

    OMIM: 604434

    KEGG: hsa:11012

    STRING: 9606.ENSP00000473047

    UniGene: Hs.57771



主站蜘蛛池模板: 中文字幕乱码免费| 亚洲日韩成人无码| 精品少妇人妻av无码久久| 国产欧美日韩| 欧美亚洲日韩国产综合电影| 成在人线av无码免费高潮水老板| 国产av福利第一精品| 精品成人毛片一区二区| 欧美性猛交xxxx乱大交| 国产成人拍精品视频午夜网站| 97精品人妻一区二区三区香蕉 | 国产精品久久久久久亚洲影视| 少妇激情av一区二区三区| 狠狠色噜噜狠狠狠狠蜜桃| 国产精品自在拍首页视频8| 偷国产乱人伦偷精品视频| 欧美老妇大p毛茸茸| 视频在线+欧美十亚洲曰本| 永久免费毛片在线播放| 亚洲欧美日韩国产自偷| 日本伊人精品一区二区三区| 国产精品久久久久久久9999| 亚洲中文字幕aⅴ无码天堂| 精品国产v无码大片在线观看| 可以免费观看的av毛片下载| 国产精欧美一区二区三区| 最近免费中文字幕中文高清百度| 欧洲熟妇色xxxxx视频| 日韩欧美精品有码在线| 国产日韩成人内射视频| 先锋影音最新色资源站| 国产自愉自愉免费精品七区 | 久久99亚洲精品久久频| 亚洲国产av美女网站| 欧美成人家庭影院| 久久中文字幕无码中文字幕有码| 久久精品国产2020| 东京热无码av一区二区| 人人超碰人摸人爱| 国产精品久久人妻无码网站蜜臀| 亚洲国产婷婷综合在线精品 |