在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLK11 Antibody, FITC conjugated

  • 中文名稱:
    KLK11兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA880069LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KLK11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KLK11
  • 別名:
    Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1, Kallikrein-11 inactive chain 2], KLK11, PRSS20 TLSP
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kallikrein-11 protein (90-282aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
  • 基因功能參考文獻:
    1. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    2. Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
    3. KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma PMID: 25123036
    4. hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. PMID: 24169449
    5. The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. PMID: 24288670
    6. Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. PMID: 23639975
    7. HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients PMID: 23647300
    8. Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. PMID: 23602830
    9. Patients harboring KLK11-positive tumors had a significantly decreased risk of death. PMID: 22429520
    10. Low KLK11 protein expression is associated with gastric cancer. PMID: 21618246
    11. For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones PMID: 21520985
    12. the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. PMID: 19242826
    13. hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. PMID: 19184568
    14. Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. PMID: 19560453
    15. may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy PMID: 11550212
    16. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. PMID: 11782391
    17. Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions. PMID: 12539228
    18. There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade. PMID: 12736044
    19. hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer PMID: 12845660
    20. KLK11 expression may play an important role in ovarian cancer development PMID: 15102682
    21. Kallikrein 11 is an independent marker of favorable prognosis in ovarian cancer patients. PMID: 15329323
    22. KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples PMID: 15893744
    23. results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
    24. The gene promoter regions of kallikrein and the corresponding transcriptional initiation sites were studied. PMID: 16911518
    25. The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
    26. Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. PMID: 19190824
    27. synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
  • 數據庫鏈接:

    HGNC: 6359

    OMIM: 604434

    KEGG: hsa:11012

    STRING: 9606.ENSP00000473047

    UniGene: Hs.57771



主站蜘蛛池模板: 欧美牲交a欧美牲交aⅴ免费真| 久久精品中文字幕有码| 亚洲丁香婷婷久久一区二区| 夜夜夜夜曰天天天天拍国产| 欧美大黑帍在线播放| 无码av免费一区二区三区四区| 熟女人妻av完整一区二区三区| 人妻少妇中文字幕乱码| 丰满的人妻hd高清日本| 国产女人高潮抽搐叫床视频| 亚洲色成人四虎在线观看| 麻豆精品传媒一二三区艾秋| 成人国产亚洲精品a区天堂| 野狼第一精品社区| 日本高清va在线播放| 欧美xxxx做受视频| 亚洲欧洲自拍拍偷午夜色| 欧美又大又粗午夜剧场免费| 国产最新av在线播放不卡| 女人被男人躁得好爽免费视频| 人妻少妇精品视频一区二区三区 | 国产极品美女到高潮无套| 国产日韩综合av在线观看一区 | 少妇做爰免费视频了| 久久久久爽爽爽爽一区老女人 | 青青草国产免费久久久下载| 久久精品aⅴ无码中文字字幕蜜桃| 狠狠色狠狠色综合久久| 青青青国产在线观看免费| 中文字幕aⅴ在线视频| 天天躁夜夜躁狠狠眼泪| 特黄做受又硬又粗又大视频小说 | 影音先锋女人aa鲁色资源| 国产真实伦在线观看视频 | 久久香蕉国产线看观看猫咪av| 精品福利视频一区二区三区| 一区二区三区四区在线 | 中国| 国产精品香蕉视频在线| 狠狠躁夜夜躁人人爽天天天天| 成年女人免费v片| 超级大爆乳奶牛被调教出奶水|