在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KLHL22 Antibody

KLHL22 Antibody

  • 中文名稱：
    KLHL22兔多克隆抗體
  • 貨號：
    CSB-PA012424GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KLHL22
  • 別名：
    KLHL22Kelch-like protein 22 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KLHL22
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
  • 基因功能參考文獻：
    1. KLHL22 plays a conserved role to mediate the activation of mTORC1 and downstream events; depletion of KLHL22 in breast cancer cells suppresses tumour growth in nude mice; therefore, pharmacological interventions targeting KLHL22 may have therapeutic potential for the treatment of breast cancer and age-related diseases PMID: 29769719
    2. CUL3/KLHL22 may contact two distinct motifs within PLK1 protein, consistent with the bivalent mode of substrate targeting. PMID: 24067371
  • 相關(guān)疾病：
    Defects in KLHL22 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Lysosome.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25888

    KEGG: hsa:84861

    STRING: 9606.ENSP00000331682

    UniGene: Hs.517419



主站蜘蛛池模板： 日日躁夜夜躁狠狠躁超碰97| 亚洲成av人最新无码| 亚洲成av人片在线观看天堂无码| 亚洲日本一区二区一本一道| 在阳台上玩弄人妻的乳球| 2020久久国产综合精品swag| 日本无码人妻一区二区色欲| 欧美乱大交xxxxx潮喷l头像| 天堂а√中文最新版地址在线| 97国产超碰一区二区三区| a三级三级成人网站在线视频 | 久久夜色撩人精品国产小说| 国产超碰人人做人人爽av大片 | 全部孕妇毛片丰满孕妇孕交| 88久久精品无码一区二区毛片| 国产日产亚洲系列最新美使用方法| 国产精品嫩草影院入口一二三| 免费无码毛片一区二区app| 午夜高清在线无码| 国产内射在线激情一区| 色妺妺视频网| 风流老熟女一区二区三区| 亚洲国产精品嫩草影院永久| 婷婷五月综合色中文字幕| 精品欧洲av无码一区二区| 久久国产精品无码hdav| 国产一区丝袜高跟鞋| 国产亚洲精久久久久久无码| 亚洲日本中文字幕天天更新| 四虎亚洲精品高清在线观看| 久久青青草原精品国产| 97人人模人人爽人人喊网 | 亚洲乱码中文论理电影| 2019日韩中文字幕mv| 无码人妻一区二区三区在线视频| 人妻avav中文系列久久| 精品乱码一区二区三四五区| 乱子伦一区二区三区| 99久久国产露脸精品国产麻豆| 日韩亚洲国产中文永久| 亚洲国产精品久久一线不卡|