在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KLHL22 Antibody, HRP conjugated

KLHL22 Antibody, HRP conjugated

  • 中文名稱：
    KLHL22兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA684469LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KLHL22 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KLHL22
  • 別名：
    KLHL22Kelch-like protein 22 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Kelch-like protein 22 protein (2-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy.
  • 基因功能參考文獻(xiàn)：
    1. KLHL22 plays a conserved role to mediate the activation of mTORC1 and downstream events; depletion of KLHL22 in breast cancer cells suppresses tumour growth in nude mice; therefore, pharmacological interventions targeting KLHL22 may have therapeutic potential for the treatment of breast cancer and age-related diseases PMID: 29769719
    2. CUL3/KLHL22 may contact two distinct motifs within PLK1 protein, consistent with the bivalent mode of substrate targeting. PMID: 24067371
  • 相關(guān)疾病：
    Defects in KLHL22 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Lysosome.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25888

    KEGG: hsa:84861

    STRING: 9606.ENSP00000331682

    UniGene: Hs.517419



主站蜘蛛池模板： 苍井空张开腿实干12次| 亚洲精品网站在线观看你懂的| 亚洲 欧美 日韩 综合aⅴ视频| 亚洲成av人片一区二区梦乃| 蜜芽久久人人超碰爱香蕉| 精品无码日韩一区二区三区不卡 | 13小箩利洗澡无码视频网站 | 人人爽人人澡人人人人妻| 一本色道久久88加勒比—综合 | 最近日本免费观看高清视频 | 亚洲熟妇另类久久久久久| 国产美女视频免费观看网址| 天天摸夜夜添狠狠添婷婷| 无码av免费精品一区二区三区| 国产又黄又刺激又高潮的网站| 成人无码在线视频网站| 国产精华av午夜在线| 无码精品人妻一区二区三区漫画| 国产亚洲精品aaaaaaa片| 中文字幕无码精品亚洲资源网 | 亚洲精品久久7777777| 日韩av无码社区一区二区三区| 西西人体www44rt大胆高清| 中文有码亚洲制服av片| 无码专区3d动漫精品免费| 最新国产久免费视频在线观看 | 国产av福利久久| 欧美老熟妇乱子| 久久精品亚洲日本波多野结衣| 老司机久久99久久精品播放免费 | 国色天香社区视频手机免费| 爽到高潮无码视频在线观看| 无码福利日韩神码福利片| 欧美熟妇丰满肥白大屁股免费视频| 免费国产精品视频在线| 中文字幕av一区二区三区| 国产美女在线精品免费观看| 草草影院精品一区二区三区| 国产精品久久久久影院亚瑟| 国产艳妇av在线观看果冻传媒| 色综合网天天综合色中文|