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  4. KLHL2 Antibody

KLHL2 Antibody

  • 中文名稱：
    KLHL2兔多克隆抗體
  • 貨號：
    CSB-PA012421LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue
      All lanes: KLHL2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 66, 67, 57 kDa
      Observed band size: 66, 67 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012421LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA012421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KLHL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KLHL2
  • 別名：
    ABP KELCH antibody; Actin binding protein Mayven antibody; Actin-binding protein Mayven antibody; kelch antibody; kelch like 2 antibody; Kelch like 2, Mayven antibody; Kelch like family member 2 antibody; Kelch like protein 2 antibody; Kelch-like protein 2 antibody; KLHL2 antibody; KLHL2_HUMAN antibody; MAV antibody; MAYVEN antibody; OTTHUMP00000219997 antibody; OTTHUMP00000219998 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Kelch-like protein 2 protein (1-155AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KLHL2 Antibody (CSB-PA012421LA01HU)，的標記方式是Non-conjugated。對于KLHL2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA012421LB01HU KLHL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA012421LC01HU KLHL2 Antibody, FITC conjugated
    Biotin CSB-PA012421LD01HU KLHL2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
  • 基因功能參考文獻：
    1. Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells. PMID: 23838290
    2. Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate. PMID: 21549840
    3. overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1 PMID: 15735724
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol.
  • 組織特異性：
    Ubiquitous. Detected throughout the brain.
  • 數據庫鏈接：

    HGNC: 6353

    OMIM: 605774

    KEGG: hsa:11275

    STRING: 9606.ENSP00000424198

    UniGene: Hs.388668



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