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  4. KLHL2 Antibody

KLHL2 Antibody

  • 中文名稱：
    KLHL2兔多克隆抗體
  • 貨號：
    CSB-PA561716
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA561716(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA561716(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 100 μg, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: CSB-PA561716(KLHL2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KLHL2
  • 別名：
    ABP KELCH antibody; Actin binding protein Mayven antibody; Actin-binding protein Mayven antibody; kelch antibody; kelch like 2 antibody; Kelch like 2, Mayven antibody; Kelch like family member 2 antibody; Kelch like protein 2 antibody; Kelch-like protein 2 antibody; KLHL2 antibody; KLHL2_HUMAN antibody; MAV antibody; MAYVEN antibody; OTTHUMP00000219997 antibody; OTTHUMP00000219998 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human KLHL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
  • 基因功能參考文獻：
    1. Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells. PMID: 23838290
    2. Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate. PMID: 21549840
    3. overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1 PMID: 15735724
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol.
  • 組織特異性：
    Ubiquitous. Detected throughout the brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6353

    OMIM: 605774

    KEGG: hsa:11275

    STRING: 9606.ENSP00000424198

    UniGene: Hs.388668



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