在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIFC1 Antibody, Biotin conjugated

  • 中文名稱:
    KIFC1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA871587LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIFC1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KIFC1
  • 別名:
    HSET antibody; HSET KNSL2 antibody; KIF C1 antibody; KIFC 1 antibody; KIFC1 antibody; KIFC1_HUMAN antibody; Kinesin family member C1 antibody; Kinesin like 2 antibody; Kinesin like protein 2 antibody; Kinesin like protein KIFC1 antibody; Kinesin related protein HSET antibody; Kinesin-like protein 2 antibody; Kinesin-like protein KIFC1 antibody; Kinesin-related protein HSET antibody; KNSL 2 antibody; KNSL2 antibody; MGC1202 antibody; MGC149736 antibody; MGC149737 antibody; Mitotic kinesin like protein 2 antibody; MKLP 2 antibody; MKLP2 antibody; RAB6 KIFL antibody; Rabkinesin 6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kinesin-like protein KIFC1 protein (337-498AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.
  • 基因功能參考文獻:
    1. Data show that kinesin-related protein HSET (HSET) is incapable of forming asters from preformed, nongrowing microtubule (non-MT) MTs, but rapidly forms MT asters in the presence of soluble (non-MT) tubulin. PMID: 29985404
    2. KIFC1 interacts with F508del-CFTR. PMID: 30066085
    3. nuclear KIFC1 (nKIFC1) correlated significantly with Ki67 in White triple-negative breast cancer (TNBCs) but not in African American (AA) TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. PMID: 28218233
    4. Results identified Stathmin as a direct target of KIFC1. PMID: 28885720
    5. The overexpression of KIFC1 was correlated closely with the progression of hepatocellular carcinoma (HCC) and poor prognosis, and suggested that the expression levels of KIFC1 are a potential prognostic biomarker for HCC. PMID: 29620256
    6. Circulating pri-miRNA-944 and 3662 can improve non-invasive potential non-small cell lung cancer detection of operable stages of SCC and AC PMID: 28964573
    7. These findings reveal a new stationary binding model that kinesin-14 KIFC1 proteins function as crosslinkers between the Golgi apparatus and the microtubules and contribute to the central positioning and structural maintenance of the Golgi apparatus. PMID: 28430595
    8. Taken together, these results suggest that up-regulation of KIFC1 may induce docetaxel resistance. PMID: 27665358
    9. Low post translational modifications of KIFC1 protein is associated with neoplasms. PMID: 28209915
    10. KIFC1 is overexpressed in GC. PMID: 27176706
    11. Association of KIFC1 gene expression and centrosome amplification with high-grade serous ovarian carcinoma. PMID: 26992853
    12. stabilization of the centrosome-spindle pole interface by the CEP215-HSET complex could promote survival of cancer cells containing supernumerary centrosomes. PMID: 26987684
    13. KIFC1 silencing significantly reduces breast cancer cell viability. PMID: 26177331
    14. Data provides the first evidence of centrosome clustering-independent activities of HSET that fuel tumor progression. PMID: 25788277
    15. We show that some are new substrates of the anaphase-promoting complex/cyclosome and validate KIFC1 and RacGAP1/Cyk4 as two such targets involved respectively in timely mitotic spindle disassembly and cell spreading PMID: 24857844
    16. Our data underscore KIFC1 as a putative biomarker that predicts worse prognosis, poor overall survival and may serve as a potential marker of onset of metastatic dissemination in ovarian cancer patients. PMID: 25028599
    17. Study demonstrates microtubule tip-tracking of human kinesin-14 HSET and show that EB1 is sufficient to induce this dynamic microtubule end localization. PMID: 24039245
    18. Acentrosomal spindle assembly mechanisms are hyperactive in cancer cells and promote HSET. PMID: 22946058
    19. we suggest that KIFC1 plays an essential role for bipolar MTOC formation and maintaining chromosomal stability in the mitosis . PMID: 23318213
    20. A case-control analysis was carried out by comparing the genotype distribution of six KIFC1 single-nucleotide polymorphisms between 93 aspirin exacerbated respiratory disease cases and 96 aspirin-tolerant asthma controls in a Korean population PMID: 22201025
    21. The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes. PMID: 19679349
    22. An analysis was made of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2. PMID: 17326138
    23. HSET has a role in controlling spindle length by cross-linking and sliding microtubules. PMID: 19116309
    24. High KIFC1 expression is associated with metastatic spread to the brain in primary non-small cell lung cancer. PMID: 19190132
    25. Chromosome congression in HSET + hNuf2 co-depleted cells required the plus-end directed motor CENP-E , which has been implicated in the gliding of mono-oriented kinetochores alongside adjacent K-fibres. PMID: 19525938

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, NCD subfamily
  • 數據庫鏈接:

    HGNC: 6389

    OMIM: 603763

    KEGG: hsa:3833

    STRING: 9606.ENSP00000393963

    UniGene: Hs.436912



主站蜘蛛池模板: 97色伦图片97综合影院| 中文字幕日韩精品亚洲一区| 天天躁夜夜踩很很踩2022| 未满十八勿入av网免费| 先锋影音av资源站av| 骚动漫十八禁在线观看| 国产狂喷潮在线观看| 欧美特级特黄aaaaaa在线看| 精品久久久久久中文字幕| 成人区精品一区二区婷婷| 奇米四色7777中文字幕| 韩国三级l中文字幕无码| 又大又紧又粉嫩18p少妇 | 国产美女被遭高潮免费网站| 日本无码人妻一区二区色欲| 中文成人无字幕乱码精品区| 艳妇乳肉豪妇荡乳xxx| 秋霞鲁丝片av无码| 国产成人无码精品久久涩吧| 国产大学生粉嫩无套流白浆| 成人动漫综合网| 日韩精品a片一区二区三区妖精| 免费人成视频在线观看播放网站| 国产精品无码久久综合网| 国产精品人妻久久久久| 亚洲最大天堂无码精品区| 久99久热只有精品国产女同| 成人a大片在线观看| 中文字幕制服丝袜人妻动态图 | 18禁网站免费无遮挡无码中文| 夜夜躁狠狠躁日日躁孕妇| 精品国产不卡在线观看免费| 中文字幕av无码专区第一页| 日韩精品人成在线播放| 风流老熟女一区二区三区| 午夜福利一区二区三区高清视频 | 一区二区国产精品精华液| 亚洲乱码日产精品bd在线看 | 亚洲国产精品ⅴa在线播放| 午夜免费啪视频| 久久国产美女精品久久|