在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KHK Antibody

  • 中文名稱:
    KHK兔多克隆抗體
  • 貨號:
    CSB-PA012157ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KHKantibody at 3.6μg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Rat kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012157ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA012157ESR1HU at dilution of 1:100
    • Immunoprecipitating KHK in Mouse liver tissue
      Lane 1: Rabbit control IgG instead of CSB-PA012157ESR1HU in Mouse liver tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA012157ESR1HU (8μg) + Mouse liver tissue (500μg)
      Lane 3: Mouse liver tissue (10μg)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KHK Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KHK
  • 別名:
    EC 2.7.1.3 antibody; Fructokinase antibody; Hepatic fructokinase antibody; Ketohexokinase antibody; Ketohexokinase isoform a antibody; KHK antibody; KHK_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Ketohexokinase protein (1-298AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
  • 基因功能參考文獻:
    1. Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft. PMID: 28954733
    2. Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. PMID: 27322374
    3. compared with normal hepatocytes, hepatocellular carcinoma (HCC) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc-dependent and heterogeneous nuclear ribonucleoprotein (hnRNP) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform. PMID: 27088854
    4. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C PMID: 26083752
    5. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease. PMID: 24876114
    6. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes. PMID: 23341889
    7. In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose. PMID: 23112875
    8. ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria. PMID: 12941785
    9. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma PMID: 16372272
    10. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. PMID: 19158351
    11. The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure. PMID: 19237742

    顯示更多

    收起更多

  • 相關疾病:
    Fructosuria (FRUCT)
  • 蛋白家族:
    Carbohydrate kinase PfkB family
  • 組織特異性:
    Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.
  • 數據庫鏈接:

    HGNC: 6315

    OMIM: 229800

    KEGG: hsa:3795

    STRING: 9606.ENSP00000260598

    UniGene: Hs.567297



主站蜘蛛池模板: 女被男啪到哭的视频网站| 免费国产午夜视频在线| 国产成人片无码视频在线观看| 国产亚洲精品成人aa片新蒲金| 性生交大片免费看| 国产成人+亚洲欧洲+综合| 久久/这里只精品99re66| 精品国产在天天在线观看| 久久国产一区二区三区| 风流少妇按摩来高潮| 国内精品伊人久久久久影院对白| 国产欧美另类久久久精品不卡| www夜插内射视频网站| 欧美大肥婆大肥bbbbb| 夜夜澡人摸人人添人人看| 2019一級特黃色毛片免費看| 欧美不卡一区二区三区| 少妇的肉体k8经典| 色情无码www视频无码区澳门| 国产办公室秘书无码精品99| 国产一精品一av一免费| 精品无人乱码一区二区三区的特点 | 一区二区免费高清观看国产丝瓜| 天堂中文8资源在线8| 亚洲人成网站在线无码| 久久久久国色av免费观看| 大陆熟妇丰满多毛xxxx| 久久婷婷色香五月综合缴缴情| 久久精品国产只有精品66| 国产人妻精品午夜福利免费| 99精品视频在线观看| 人妻综合专区第一页| 亚洲成av人在线观看网站| 少妇极品熟妇人妻| 国产成人午夜福利在线播放| 人妻丝袜无码国产一区| 国产成人无码精品亚洲| 人妻人人做人做人人爱| 翘臀后进少妇大白嫩屁股| 舌头伸进去搅动好爽视频| 精品欧洲av无码一区二区三区 |