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KCNK16 Antibody, FITC conjugated

  • 中文名稱:
    KCNK16兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA850434LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KCNK16 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNK16
  • 別名:
    KCNK16; TALK1; Potassium channel subfamily K member 16; 2P domain potassium channel Talk-1; TWIK-related alkaline pH-activated K(+ channel 1; TALK-1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
  • 基因功能參考文獻:
    1. data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes. PMID: 28928238
    2. The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion. PMID: 28403169
    3. These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion. PMID: 26239056
    4. at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas. PMID: 12724142
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性:
    Highly expressed in pancreas. Not detectable in the other tissues tested.
  • 數據庫鏈接:

    HGNC: 14464

    OMIM: 607369

    KEGG: hsa:83795

    STRING: 9606.ENSP00000391498

    UniGene: Hs.287765



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