在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNK1 Antibody

  • 中文名稱:
    KCNK1兔多克隆抗體
  • 貨號:
    CSB-PA987381
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA987381(KCNK1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KCNK1
  • 別名:
    KCNK1; HOHO1; KCNO1; TWIK1; Potassium channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1; Potassium channel K2P1; Potassium channel KCNO1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human KCNK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors. Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes. Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents. Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential. Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Required for normal ion and water transport in the kidney. Contributes to the regulation of the resting membrane potential of pancreatic beta cells. The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes.
  • 基因功能參考文獻:
    1. Dynamics of the TWIK-1 Channel PMID: 27558721
    2. Our data indicate that TWIK-1 has a highly conserved role in cardiac function and is required for normal heart rate and atrial morphology. Despite the functional importance of TWIK-1 in the atrium, genetic variation in KCNK1 is not a common primary cause of human AF. PMID: 27103460
    3. TWIK-1 protein possesses a hydrophobic barrier deep within the inner pore PMID: 25001086
    4. Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells PMID: 21964404
    5. study presents the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1; an extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals PMID: 22282804
    6. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability. PMID: 21653227
    7. TWIK1 is internalized via a dynamin-dependent mechanism and addressed to the recycling endosomal compartment. Mutation in its cytoplasmic C terminus (I293A,I294A) stabilizes TWIK1 at the plasma membrane, resulting in robust currents. PMID: 19959478
    8. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage. PMID: 15820677
    9. support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes PMID: 19571146

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Recycling endosome. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cell projection. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性:
    Detected in bronchial epithelial cells. Detected in heart left atrium and left ventricle. Detected in cardiac myocytes (at protein level). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and l
  • 數據庫鏈接:

    HGNC: 6272

    OMIM: 601745

    KEGG: hsa:3775

    STRING: 9606.ENSP00000355580

    UniGene: Hs.208544



主站蜘蛛池模板: 国产成人精品一区二区视频| 多人伦交性欧美| 天堂岛国av无码免费无禁网站| 大伊香蕉精品一区二区| 成人国内精品久久久久一区| 亚洲国产精品成人久久蜜臀| 男女猛烈无遮挡免费视频| 国产亚洲欧美日韩夜色凹凸成人 | 国产精品国产三级在线专区| 深夜国产一区二区三区在线看| 亚洲欧洲日产韩国在线看片| 婷婷激情综合色五月久久竹菊影视 | 日韩中文高清在线专区| 四虎影在永久在线观看| 国产av国片精品有毛| 亚洲丁香婷婷久久一区二区| 中文在线8资源库| 久久人人爽人人爽人人爽| 国产无套护士在线观看| 亚洲国产精品无码一区二区三区| 少妇无码av无码专区| 精品国产人成亚洲区| 成a人片亚洲日本久久| 日韩欧美亚洲综合久久影院d3 | 一边摸一边做爽的免费视频日本| 潮喷失禁大喷水aⅴ无码| 2020精品国产自在现线看| 亚洲小说图区综合在线| 久久99国产综合精品女同| 人妻无码中字在线a| 69sex久久精品国产麻豆| 中文字幕人妻少妇引诱隔壁| 国内精品乱码卡一卡2卡三卡新区 亚洲爆乳成av人在线视菜奈实 | 无码专区―va亚洲v专区在线| 熟妇人妻不卡中文字幕| 97久久精品人妻人人搡人人玩| 精品无码久久久久久久久| 国产成人午夜福利在线小电影| 波多野结衣一区二区免费视频 | 国产成人精品免费视频大全五级| 在线精品国产大象香蕉网|