在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNK1 Antibody, FITC conjugated

  • 中文名稱:
    KCNK1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA012062LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KCNK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNK1
  • 別名:
    KCNK1; HOHO1; KCNO1; TWIK1; Potassium channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1; Potassium channel K2P1; Potassium channel KCNO1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium channel subfamily K member 1 protein (268-336AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors. Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes. Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents. Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential. Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Required for normal ion and water transport in the kidney. Contributes to the regulation of the resting membrane potential of pancreatic beta cells. The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes.
  • 基因功能參考文獻(xiàn):
    1. Dynamics of the TWIK-1 Channel PMID: 27558721
    2. Our data indicate that TWIK-1 has a highly conserved role in cardiac function and is required for normal heart rate and atrial morphology. Despite the functional importance of TWIK-1 in the atrium, genetic variation in KCNK1 is not a common primary cause of human AF. PMID: 27103460
    3. TWIK-1 protein possesses a hydrophobic barrier deep within the inner pore PMID: 25001086
    4. Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells PMID: 21964404
    5. study presents the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1; an extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals PMID: 22282804
    6. ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability. PMID: 21653227
    7. TWIK1 is internalized via a dynamin-dependent mechanism and addressed to the recycling endosomal compartment. Mutation in its cytoplasmic C terminus (I293A,I294A) stabilizes TWIK1 at the plasma membrane, resulting in robust currents. PMID: 19959478
    8. Removal of the peptide adduct by SUMO protease reveals K2P1 to be a K+-selective, pH-sensitive, openly rectifying channel regulated by reversible peptide linkage. PMID: 15820677
    9. support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes PMID: 19571146

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Recycling endosome. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cell projection. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 組織特異性:
    Detected in bronchial epithelial cells. Detected in heart left atrium and left ventricle. Detected in cardiac myocytes (at protein level). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and l
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6272

    OMIM: 601745

    KEGG: hsa:3775

    STRING: 9606.ENSP00000355580

    UniGene: Hs.208544



主站蜘蛛池模板: 久久精品国产精品亚洲艾草网 | 国产在热线精品视频| 亚洲欧美国产精品专区久久| 亚洲一区av无码少妇电影| 国产亚洲精品久久久久动漫| 国产成 人 综合 亚洲| 柠檬福利第一导航在线| 精品高潮呻吟99av无码视频| 免费国产va在线观看| 日韩免费一区二区三区高清| 果冻传媒18禁免费视频| 精品无码无人网站免费视频| 日韩中文高清在线专区| 中文字字幕在线乱码视频| 无码人妻精品一区二区三区蜜桃 | 天堂av男人在线播放| 超级碰97直线国产免费公开| 国产成人精品日本亚洲语音| 极品白嫩的小少妇| 国产精品久久久久av| 人人揉揉揉香蕉大免费| 国产欧美精品一区二区色综合| 国产精品久久久久久妇女6080| 亚洲卡1卡2卡新区网站| 国产初高中生粉嫩无套第一次| 国产亚洲人成无码网在线观看| 欧美怡红院免费全部视频| k频道国产在线观看| 亚洲a综合一区二区三区| 可以免费观看的av毛片下载| 少妇无码太爽了不卡视频在线看| 人妻夜夜爽天天爽三区麻豆av网站 | 国产福利自产拍| 一本色综合亚洲精品蜜桃冫| 成人内射国产免费观看| 玩弄了裸睡少妇人妻野战| 久久人搡人人玩人妻精品| 亚洲日韩乱码久久久久久| 182tv午夜福利在线地址二| 妲己丰满人熟妇大尺度人体艺| 国产激情久久久久久熟女老人|